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Purified anti-human Delta-like protein 1 (DLL1) Antibody

Pricing & Availability
Clone
MHD1-314 (See other available formats)
Regulatory Status
RUO
Other Names
DLL1, Delta1, DL1, Delta, delta-like 1, DLL
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
MHD1-314_PE_012510
Human DLL1 transfected CHO cells stained with MHD1-314 PE
  • MHD1-314_PE_012510
    Human DLL1 transfected CHO cells stained with MHD1-314 PE
Cat # Size Price Save
346402 100 µg ¥31,020
Description

Delta-like protein 1 is a type I transmembrane protein. The mature form consist of an extracellular domain of 528 amino acids (aa) that contain a DSL domain and eight tandem EGF repeats; the transmembrane region is 23 aa long and has a 155 aa cytoplasmic domain. After the binding of Notch receptors, the extracellular and cytoplasmic domains are cleaved, and the later is translocated into the cell nucleus to regulate gene expression. Delta-like protein 1 is expressed in heart and pancreas and in a lower amount in brain and muscle. During fetal life, it is transiently expressed during gastrulation and early organogenesis and its expression remains through adult life in hematopoietic tissues and the cortico-medullary region of the thymus.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
hu DLL1-hu IgG Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2092810 (BioLegend Cat. No. 346402)

Antigen Details

Structure
Type I transmembrane protein, the mature form consist of a 528 aa extracellular domain which contains a DSL domain and eight tandem EGF repeats, a 23 aa transmembranal region and a 155 aa cytoplasmic domain. After Notch binding, a consecutive cleavage of
Distribution
Expressed in heart and pancreas, with lower expression in brain and muscle. Is expressed in the cortico-medullary region of the thymus and in the fetal and adult human hematopoietic tissues. In addition, is expressed transiently during gastrulation and early organogenesis in the fetus.
Function
Regulates the differentiation and survival of a variety of cell types including B, T and dendritic cells, conditional deletion of Dll1 postnatally completely abrogates MZ B-cell development
Ligand/Receptor
Notch receptors
Cell Type
Dendritic cells, Tregs
Biology Area
Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
Adhesion Molecules
Antigen References

1. Fu L, et al. 2009. Anticancer Res. 29:3967
2. Zhou J, et al. 2009. Immunity 30:845
3. Radke AL, et al. 2009. Blood 113:3092
4. Six EM, et al. 2004. J. Biol. Chem. 279:55818
5. Hozumi K, et al. 2004. Nat Immunol. 2004 5:638

Gene ID
28514 View all products for this Gene ID
UniProt
View information about DLL1 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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