Purified anti-human FPR1 Antibody anti-FPR1

Clone: W15086B (See other available formats)
Regulatory Status: RUO
Other Names: fMet-Leu-Phe receptor 1, FMLP, FPR, fMLF-R
Isotype: Mouse IgG1, κ
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Product Citations: publications

W15086B_PURE_FPR1_Antibody_040717 — Human peripheral blood leukocytes were stained with purified anti-human FPR1 (Clone W15086B) (filled histogram) or purified mouse IgG1 κ isotype control (open histogram), followed by goat anti-mouse IgG PE. Data shown was gated on granulocyte population.

Cat #	Size	Price	Save
391602	100 µg	¥50,380

Description

FPR1 (Formyl Peptide Receptor 1), a G protein-coupled receptor consisting of seven transmembrane domains, is expressed on phagocytic cells and other cell types such as monocytes. FPR1 is a high affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. Endogenous peptide ligands for this receptor have also been identified. FPR1 mediates the response to invasion of the host by microbial pathogens and is important in host defense and inflammation.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Full length human FPR1 transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2687020 (BioLegend Cat. No. 391602)

Antigen Details

Structure: Seven transmembrane domains, G-protein coupled receptor (GPCR)
Distribution: Monocytes, Neutrophils
Function: Chemotaxis
Ligand/Receptor: N-formylated peptides, Ac9-25, FAM19A4, Annexin A1
Cell Type: Monocytes, Neutrophils, Eosinophils
Biology Area: Immunology, Innate Immunity
Antigen References: 1. Boulay F, et al. 1990. Biochemistry 29:11123.
2. Ye RD, et al. 2009. Pharmacol. Rev. 61:119.
3. Prossnitz ER, et al. 1999. Biochemistry 38:2240.
4. Wang W, et al. 2015. Cell Mol. Immunol. 12:615.
Gene ID: 2357 View all products for this Gene ID
UniProt: View information about FPR1 on UniProt.org

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Other Formats

View All FPR1 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human FPR1	W15086B	FC
FITC anti-human FPR1	W15086B	FC
PerCP/Cyanine5.5 anti-human FPR1	W15086B	FC
PE anti-human FPR1	W15086B	FC
APC anti-human FPR1	W15086B	FC

Certificate of Analysis

Go To Top Version: 0 Revision Date: 04/10/2017

For Research Use Only. Not for diagnostic or therapeutic use.

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