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Purified anti-human FPR3 (FPRL2) Antibody

Pricing & Availability
Clone
K102B9 (See other available formats)
Regulatory Status
RUO
Other Names
FMLPY, FPRH2, formyl peptide receptor like 2, FPR3, formyl peptide receptor 3
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
K102B9_Purified_FPRL2_Antibody_FC_040113
FPRL2 transfected CHO cells (top) or human peripheral blood monocytes (bottom) were stained with purified FPRL2 (clone K102B9, filled histograms) or mouse IgG2a, κ isotype control (open histograms), followed by anti-mouse IgG PE.
  • K102B9_Purified_FPRL2_Antibody_FC_040113
    FPRL2 transfected CHO cells (top) or human peripheral blood monocytes (bottom) were stained with purified FPRL2 (clone K102B9, filled histograms) or mouse IgG2a, κ isotype control (open histograms), followed by anti-mouse IgG PE.
  • K102B9_Purified_FPRL2_Antibody_FC_2_040113
Cat # Size Price Save
357702 100 µg ¥58,300
Description

FPR3, also known as FPRL2, belongs to the formyl peptide receptor family which includes FPR1, FPR2, and FPR3.  Monocytes express FPR1, 2, and 3; upon differentiation into macrophages, expression of these receptors is maintained. Two ligands, humanin and F2L have been identified.  Humanin is expressed in the heart, skeletal muscle, kidney, and liver but is not expressed in the immune system.  F2L is a heme-binding protein first identified in the spleen.  Binding of FPRL2 and F2L induces Ca2+ mobilization and neutrophil chemotaxis.  Low level of expression of FPRL2 has also been reported on NK cells.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
DNA vaccine containing full length FPRL2.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2561982 (BioLegend Cat. No. 357702)

Antigen Details

Structure
40 kD, seven transmembrane protein
Distribution
Monocytes, macrophages, basophils, plasmacytoid dendritic cells
Function
Neutrophil chemotaxis and degranulation
Ligand/Receptor
Humanin and FPRL2 ligand (F2L)
Cell Type
Monocytes, Macrophages, Basophils, Dendritic cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Devosse T, et al. 2009. J. Immunol. 182:4974.
2. Yang D, et al. 2002. J. Leukoc. Biol. 72:598.
3. Harada M, et al. 2004. Biochem. Biophys. Res. Commun. 324:255.
4. Migeotte I, et al. 2005. J. Exp. Med. 201:83.
5. Gao JL, et al. 2007. J. Immunol. 178:1450.

Gene ID
2359 View all products for this Gene ID
UniProt
View information about FPR3 on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 04/05/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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