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- Clone
- K07JP05 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- G Protein-Coupled Receptor 83, GIR, Glucocorticoid Induced Receptor, GPR72, G Protein-Couple Receptor 72, KIA1540, JP05
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
GPR83 transfected CHO-K1 cells were stained with purified anti-human GPR83 (clone K07JP05, filled histogram), or purified mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG PE.
GPR83, also known as GIR, is a seven-pass membrane protein that belongs to the G-protein coupled receptor 1 family. GPR83 is an orphan GPR homologous to tachykinin and neuropeptide Y (NPY) receptors. GPR83 is expressed in the brain and in both murine and human Treg cells. GPR83 is reported to regulate core body temperature and there are four isoforms of GPR83. Studies have suggested that isoform-4, but not isoform-1, is associated with the suppressive functions of Treg cells. The precise role of GPR83 in Treg function is unclear.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- DNA vaccine with full coding sequence of human GPCR cloned in expression vector.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2564189 (BioLegend Cat. No. 363302)
Antigen Details
- Structure
- Orphan GPR, homologous to tachykinin and neuropeptide Y (NPY) receptors. Belongs to the G-protein coupled receptor 1 family and is approximately 48 kD.
- Distribution
- Found on neurons in the brain and Tregs.
- Function
- Induces Foxp3 expression in CD4+ T cells, and may be involved in thermoregulation.
- Interaction
- Forms a heterodimer with Ghsr1a or homodimerizes.
- Cell Type
- Neurons, Tregs
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. De Moerlooze L, et al. 2000. Cytogenet. Cell Genet. 90:146.
2. Hansen W, et al. 2006. J. Immunol. 177:209.
3. Sugimoto N et al. 2006. Int. Immunol. 18:1197.
4. Lu LF, et al. 2007. Mol. Cell Biol. 27: 8065.
5. Müller TD, et al. 2013. Nat. Commun. 4:1968. - Gene ID
- 10888 View all products for this Gene ID
- UniProt
- View information about GPR83 on UniProt.org
Other Formats
View All GPR83 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human GPR83 | K07JP05 | FC |
| PE anti-human GPR83 | K07JP05 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human GPR83
GPR83 transfected CHO-K1 cells were stained with purified an... -
PE anti-human GPR83
GPR83 transfected CHO-K1 cells were stained with anti-human ...
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