- Clone
- K125H4 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Mas-related G-protein coupled receptor member X2, MRGPRX2
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
MRGX2 (Mas-related G-protein coupled receptor member X2) is a 36 kD, seven transmembrane protein expressed on mast cells and sensory neurons from the dorsal root ganglia. MRGX2 is involved in mast cell-degranulation, and may regulate the function and development of sensory neurons. Originally described as an orphan receptor, it has been reported MRGX2 binds defensins and costistatin.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- DNA vaccine containing the full length gene of human MRGX2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2562299 (BioLegend Cat. No. 359002)
Antigen Details
- Structure
- Seven transmembrane domains, 36 kD, member of the GPCR family
- Distribution
-
Mast cells, sensory neurons from the dorsal root ganglia
- Function
- Involved in mast cell-degranulation, may regulate function and development of sensory neurons
- Interaction
- Coupled to G-proteins Gαq and Gαi
- Ligand/Receptor
- Defensins, cortistatin
- Cell Type
- Mast cells
- Biology Area
- Immunology, Innate Immunity
- Antigen References
-
1. Subramanian H, et al. 2013. J. Immunol. 191:345.
2. Subramanian H, et al. 2011. J. Biol. Chem. 286:44739.
3. Yang S, et al. 2005. Gene. 352:30.
4. Robas N, et al. 2003. J. Biol. Chem. 278:44400. - Gene ID
- 117194 View all products for this Gene ID
- UniProt
- View information about MRGX2 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All MRGX2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human MRGX2 | K125H4 | FC |
PE anti-human MRGX2 | K125H4 | FC |
APC anti-human MRGX2 | K125H4 | FC |
PE/Cyanine7 anti-human MRGX2 | K125H4 | FC |
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Purified anti-human MRGX2
Human MRGX2 transfected CHO cells were stained with purified... -
PE anti-human MRGX2
Human MRGX2 transfected CHO cells were stained with MRGX2 (c... -
APC anti-human MRGX2
Human MRGX2 transfected CHO cells were stained with MRGX2 (c... -
PE/Cyanine7 anti-human MRGX2
Human MRGX2 transfected CHO cells were stained with MRGX2 (c...
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