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- Clone
- UK98/6 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Urokinase-type Plasminogen activator, urokinase, Plasminogen activator, ATF, BDPLT5, QPD, UPA, URK
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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NCI-H1299 cells (a non-small cell lung cancer cell line) were stained with purified uPA (clone UK98/6) (filled histogram) or purified mouse IgG1, κ isotype control, followed by anti-mouse IgG PE.
uPA is a serine protease. It is produced as a single-chain protein containing serine protease domain, Kringle domain, and growth factor domain. It is proteolyticaly cleaved between Lys158 and Ile159; the two resulting chains are kept together as a dimer by a disulfide bond. The primary function of uPA is to convert plasminogen into plasmin by specific cleavage of an Arg-Val bond in plasminogen. uPA is also involved in the degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Alternatively spliced transcript variants encoding different isoforms have been found for uPA; a specific polymorphism of uPA may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified urokinase
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
ICC, IHC - Reported in the literature, not verified in house - Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Heidtmann H, et al. 1989. Cancer Research 49:6960.
- Schwartz-Albiez R, et al. 1992. Br. J. Cancer 65:51.
- Product Citations
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- RRID
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AB_2566427 (BioLegend Cat. No. 369002)
Antigen Details
- Structure
- 411-aa residue zymogen that is cleaved into two chains and forms heterodimer.
- Distribution
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Urine, blood, and extracellular matrix.
- Function
- Serine protease.
- Ligand/Receptor
- u-PA Receptor, CD87.
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Antigen References
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1. Riccio A, et al. 1985. Nucleic Acids Res. 13:2759.
- Gene ID
- 5328 View all products for this Gene ID
- UniProt
- View information about uPA on UniProt.org
Other Formats
View All uPA (PLAU) Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human uPA (PLAU) | UK98/6 | FC,ICC,IHC |
| PE anti-human uPA (PLAU) | UK98/6 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human uPA (PLAU)
NCI-H1299 cells (a non-small cell lung cancer cell line) wer... -
PE anti-human uPA (PLAU)
Human lung cancer cell line H1299 cells were stained with u-...
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