- Clone
- Poly18339 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Keratin, type I cytoskeletal 15, CK-15, cytokeratin-15, keratin-15, beta, keratin-15, basic keratin-15, K15, cytokeratin 15, cytokeratin15
- Isotype
- Chicken IgY
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a member of the type I cytokeratin family. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chain. Keratin 15 has been associated with diseases such as malignant syringoma and morpheaform basal cell carcinoma.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Reported Reactivity
- Non-Human Primate
- Antibody Type
- Polyclonal
- Host Species
- Chicken
- Immunogen
- This antibody was raised against a peptide sequence derived from the C-terminus of the human keratin 15 protein, CDGQVVSSHKREI.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
WB - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 μg/ml is suggested. For Western blotting, a concentration range of 1.0 - 10 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2616894 (BioLegend Cat. No. 833904)
Antigen Details
- Structure
- Keratin 15 is a 456 amino acid protein with a molecular mass of 49 kD.
- Distribution
-
Tissue distribution: skin.
Cellular distribution: extracellular, nucleus, and cytoskeleton. - Function
- Keratin 15 is responsible for maintaining the structural integrity of mammalian epithelial cells.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Intermediate Filaments
- Antigen References
-
1. Liu Y, et al. 2003. J. Invest. Dermatol. 121(5)963. PubMed
2. Jih DM, et al. 1999. J. Cutan. Pathol. 26(3):113. PubMed
3. Leube RE, et al. 1988. J. Cell Biol. 106(4):1249. PubMed - Gene ID
- 3866 View all products for this Gene ID
- UniProt
- View information about Keratin 15 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Keratin 15 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Keratin 15 | Poly18339 | IHC-P,WB |
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