Purified anti-mouse CD268 BAFF-R Antibody anti-CD268

Clone: 7H22-E16 (See other available formats)
Regulatory Status: RUO
Other Names: BR3, BAFFR, BAFF receptor, TNFRSF13C, B cell-activating factor receptor, BLys receptor 3
Isotype: Rat IgG1, κ
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Product Citations: publications

C57BL/6 mouse splenocytes stained with purified 7H22-E16 conjugated to PE (upper) or rat IgG1 PE isotype control (lower panel) and CD45R/B220 APC

Cat #	Size	Price	Save
134102	500 µg	¥64,460

Description

BAFF (B cell-activating factor belonging to the TNF family) receptor (BAFF-R) is one of the three receptors that bind to BAFF. It is a type III transmembrane TNF receptor family member. BAFF-R is expressed at high levels in resting B cells and at lower levels in activated B cells, a small subset of activated/memory CD4⁺ T cells. It is a major mediator of BAFF dependent co-stimulatory response in peripheral B and T cells. It was reported that the mice expressing defective BAFF-R have disrupted B cell maturation. BAFF receptor appears to be particularly important for the regulation of normal B cell survival and maturation, as well as in the pathophysiology of aggressive B-cell malignancies and autoimmune diseases.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse BAFF receptor transfected rat RBL cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_1626123 (BioLegend Cat. No. 134102)

Antigen Details

Structure: A type III transmembrane TNF receptor family member
Distribution: Expressed on most B cells, a small subset of CD4⁺ T cells.
Function: Play an importance role in B cell development, maturation, and survival.
Ligand/Receptor: BAFF (BLyS)
Cell Type: B cells, T cells
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Thompson JS, et al. 2001. Science 293:2108.
2. Schiemann B, et al. 2001. Science 293:2111.
3. Batten M, et al. 2000. J. Exp. Med. 192:1453.
4. Fu L, et al. 2009. Blood 113:4627.
Gene ID: 72049 View all products for this Gene ID
UniProt: View information about CD268 on UniProt.org

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Description	Clone	Applications
Purified anti-mouse CD268 (BAFF-R)	7H22-E16	FC
PE anti-mouse CD268 (BAFF-R)	7H22-E16	FC
Alexa Fluor® 647 anti-mouse CD268 (BAFF-R)	7H22-E16	FC
Ultra-LEAF™ Purified anti-mouse CD268 (BAFF-R)	7H22-E16	FC,Block

Certificate of Analysis

Go To Top Version: 1 Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

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