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- Clone
- TX52 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD300c/d, MAIR-II, LMIR-II, CLM-4, DIgR1, CLM-6
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
MAIR-II transfected cells (ST88) were stained with purified anti-mouse CD300c/d (clone TX52) (filled histogram) or purified rat IgG2b isotype control (open histogram), followed by anti-rat IgG PE.
CD300 receptors are a group of type I transmembrane proteins, which belong to the Ig superfamily. In mice, nine members have been reported with different nomenclature systems, such as myeloid-associated Ig-like receptor (MAIR), leukocyte mono-Ig-like receptor (LMIR), DC-derived Ig-like receptor (DIgR), and CMRF-35-like molecule (CLM). The CD300 molecules act as either activating or inhibitory receptors through interactions with adaptor molecules, such as PAD12, DAP10, and FcRγ. Despite sharing high homology with CD300a, CD300c (LMIR-II) does not share its inhibitory function. CD300c has been found to activate a variety of cell types and induce proinflammatory molecule production. CD300d may be involved with the regulation/formation of CD300 complexes on the cell surface.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- MAIR-II transfected Ba/F3
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
WB - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Additional reported applications (for the relevant formats) include: Western blotting1.
- Product Citations
-
- RRID
-
AB_2563673 (BioLegend Cat. No. 148002)
Antigen Details
- Structure
- Type I transmemrane protein, Ig superfamily
- Distribution
- B cell subsets, macrophages, dendritic cells
- Interaction
- DAP12, DAP10, FcRγ
- Ligand/Receptor
- Phosphatidylserine
- Cell Type
- B cells, Macrophages, Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Yotsumoto K, et al. 2003. J. Exp. Med. 198:223.
2. Martinez-Barriocanal A, et al. 2010. J. Biol. Chem. 285:41781.
3. Borrego F. 2013. Blood. 121:1951.
4. Lankry D, et al. 2013. Eur. J. Immunol. 43:2151. - Gene ID
- 387565 View all products for this Gene ID 140497 View all products for this Gene ID
- UniProt
- View information about CD300c/d on UniProt.org
Related FAQs
Other Formats
View All CD300c/d Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD300c/d | TX52 | FC |
| PE anti-mouse CD300c/d | TX52 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD300c/d
MAIR-II transfected cells (ST88) were stained with purified ... -
PE anti-mouse CD300c/d
CD300c/d/MAIR-II transfectants (ST88) cells were stained wit...
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