Purified anti-mouse CD365 Tim-1 Antibody anti-CD365

Clone: RMT1-4 (See other available formats)
Regulatory Status: RUO
Other Names: T cell immunoglobulin and mucin domain containing protein-1, T cell and airway phenotype regulator (Tapr), hepatitic virus cellular receptor 1, CD365
Isotype: Rat IgG2b, κ
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RMT1-4_Purified_091207 — Mouse Tim-1 transfected cells stained with purified anti-mouse CD365 (Tim-1, clone RMT1-4), followed by anti-rat IgG FITC

Cat #	Size	Price	Save
119502	500 µg	¥86,460

Description

CD365 (Tim-1) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4⁺ lymphocytes especially on Th₂ cells and has been implicated to play a critical role in the development of atopic disease and other Th₂-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation. Tim-1 is an endogenous ligand for LMIR5/CD300b.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_345368 (BioLegend Cat. No. 119502)

Antigen Details

Structure: Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD.
Distribution: Developmentally regulated; highly expressed in embryonic development in blastocysts. Expressed on activated CD4⁺ lymphocytes, especially Th2 cell lines.
Function: Binds hepatitis virus, may play a critical role in immune responses and the development of atopic diseases (in particular airway hyperreactivity).
Ligand/Receptor: Binds hepatitis A virus in humans, Tim-4, LMIR5/CD300b
Cell Type: T cells, Th2
Biology Area: Immunology, Inhibitory Molecules
Molecular Family: CD Molecules
Antigen References: 1. McIntire JJ, et al. 2001. Nature Immunol. 2:1109.
2. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
3. Wills-Karp M, et al. 2001. Nat. Rev. Immunol. 1:69.
4. Meyers JH, et al. 2005. Nat. Immunol. 6(5):455.
Gene ID: 171283 View all products for this Gene ID
UniProt: View information about CD365 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD365 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse CD365 (Tim-1)	RMT1-4	FC
Biotin anti-mouse CD365 (Tim-1)	RMT1-4	FC
PE anti-mouse CD365 (Tim-1)	RMT1-4	FC
Brilliant Violet 421™ anti-mouse CD365 (Tim-1)	RMT1-4	FC

Certificate of Analysis

Go To Top Version: 3 Revision Date: 01/14/2015

For Research Use Only. Not for diagnostic or therapeutic use.

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