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- Clone
- A17207I (See other available formats)
- Regulatory Status
- RUO
- Other Names
- PD-1 homolog, Dies1, B7-H5
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mouse splenocytes were stained with purified PD-1H (VISTA) (clone A17207I) (left) or rat IgG2a, κ isotype control (right), followed by anti-rat IgG FITC. Cells were costainined with CD8a APC.
PD-1H, also known as VISTA, is a 309 aa type I transmembrane protein, composed of seven exons. PD-1H has one Ig-V like domain, and its sequence is similar to the Ig-V domains of the members of CD28 and B7 families. PD-1H is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It has been proposed that PD-1H can be useful to modulate the host immune response to allogeneic transplants.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse VISTA protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone A17207I antibody is able to completely block the staining of clone MH5A antibody.
- RRID
-
AB_2892328 (BioLegend Cat. No. 159602)
Antigen Details
- Structure
- Type I transmembrane protein, member of the CD28 family
- Distribution
-
Macrophages, dendritic cells, neutrophils, NK cells, naïve and activated T cells
- Function
- Negative regulation of immune response
- Ligand/Receptor
- PSGL-1
- Cell Type
- Dendritic cells, Macrophages, Neutrophils, NK cells, T cells
- Biology Area
- Immunology, Inhibitory Molecules
- Antigen References
-
- Flies DB, et al. 2011. J. Immunol. 187:1537.
- Wang Li, et al. 2011. J. Exp Med. 208:577.
- Gene ID
- 74048 View all products for this Gene ID
- UniProt
- View information about PD-1H on UniProt.org
Other Formats
View All PD-1H Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse PD-1H (VISTA) | A17207I | FC |
| Purified anti-mouse PD-1H (VISTA) | A17207I | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-mouse PD-1H (VISTA)
C57BL/6 mouse splenocytes were stained with CD8a APC and ant... -
Purified anti-mouse PD-1H (VISTA)
C57BL/6 mouse splenocytes were stained with purified PD-1H (...
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