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- Clone
- F2.67 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TCR Vgamma7, TCR Vγ5 (Garman nomenclature), TRGV7, GV4S1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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C57BL/6 splenocytes were stained with purified anti-mouse TCR Vγ7 (clone F2.67) (left) or purified mouse IgG2a, κ isotype control (right) followed by PE rat anti-mouse IgG2a. Cells were co-stained with FITC anti-CD3 and APC anti-γδ TCR. Data shown are CD3+ gated cells.
T cell receptor (TCR) is a heterodimer consisting of α/β chains (αβ T cells) or γ/δ chains (γδ T cells). γδ T cells are a minor T cell population in the body, with the usage of γ and δ often associated with specific anatomical localization. Vγ7-expressing γδ T cells are resident in the intestinal epithelium and contain a high proportion of extrathymically generated cells. It has been reported that butyrophilin-like molecules Btnl1 with Btnl6 are important in Vγ7+ T cell responses.
The F2.67 antibody reacts specifically with mouse TCR Vγ7 (as referred to by the Tonegawa nomenclature system for TCR γ and δ chains). Mouse TCR Vγ7 is also known as TCR Vγ5 under the Garman nomenclature system.
Several TCR γ and δ chain nomenclature systems exist. In order to consolidate the various nomenclature systems, we have created charts for corresponding names across some of the most popular naming methods. Click here to see charts.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Mouse hybridoma expressing anti Vγ7Vδ5 TCR
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Pereira P, et al. 2000. Eur J Immunol. 30:1988-97.
- Khairallah C, et al. 2015. PLoS Pathog. 11:e1004702.
- Di Marco Barros R, et al. 2016. Cell. 167:203-218.
- Product Citations
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- RRID
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AB_2888774 (BioLegend Cat. No. 161702)
Antigen Details
- Structure
- Heterodimer with γ and δ chain
- Distribution
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Subset of γδ T cells
- Function
- Antigen recognition
- Interaction
- CD3
- Cell Type
- Lymphocytes, T cells, Thymocytes
- Biology Area
- Adaptive Immunity, Immunology, Innate Immunity
- Molecular Family
- TCRs
- Gene ID
- 21641 View all products for this Gene ID
- UniProt
- View information about TCR Vgamma7, TCR Vγ5 (Garman nomenclature), TRGV7, GV4S1 on UniProt.org
Related FAQs
Other Formats
View All TCR Vγ7 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse TCR Vγ7 Antibody | F2.67 | FC |
Customers Also Purchased
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse TCR Vγ7 Antibody
C57BL/6 splenocytes were stained with purified anti-mouse TC...
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