- Clone
- 14D10A24 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Paired box protein Pax-9
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
PAX9 is a transcription factor belonging to the PAX family, which is composed of nine members defined by the presence of a paired box domain responsible for DNA binding. PAX9 is expressed at the E10 stage and downregulated at the bell stage. It is controlled by Fgf/Bmp signaling and plays an essential role in tooth development. PAX9 deficient mice fail to form teeth and show developmental arrest at the bud stage. In humans, heterozygous mutation in PAX9 is associate with tooth agenesis. These findings support the role of PAX9 in tooth development.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human PAX9 recombinant protein (131-341 aa)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody binds non-specifically to a protein over 250kDa therefore it is not recommended to use in immunofluorescence staining.
- Product Citations
-
- RRID
-
AB_2562877 (BioLegend Cat. No. 658202)
Antigen Details
- Structure
- 341 amino acids in human and 342 amino acids in mouse, with predicted molecular weight of 36 kD. Contains a paired box domain responsible for DNA binding.
- Distribution
-
Nucleus.
- Function
- PAX9 is a transcription factor essential for tooth development.
- Interaction
- PAX9 interacts with KDM5B.
- Biology Area
- Cell Biology, Immunology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
1. Almeida CV, et al. 2010. J. Appl. Oral Sci. 18:482.
2. Wang Y, et al. 2009. Cells Tissues Organs. 189:80.
3. Pereira TV, et al. 2006. Proc. Natl. Acad. Sci. USA. 103:5676.
4. Mensah JK, et al. 2004. J. Biol. Chem. 279:5924.
5. Peters H, et al. 1998. Genes Dev. 12:2735.
6. Guala A, et al. 2008. Int. J. Paediatr. Dent. 18:441. - Gene ID
- 5083 View all products for this Gene ID
- UniProt
- View information about PAX9 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All PAX9 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-PAX9 | 14D10A24 | WB,ICC |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-PAX9
Total cell lysates (15 µg protein) from HeLa (lane 1), PC3 (...
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