- Clone
- 6A6-4H3-7A3 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- PRDX1, Natural killer cell-enhancing factor A, NKEF-A, Proliferation-associated gene protein, PAG, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, Thioredoxin-dependent peroxiredoxin 1, PAGA, PAGB, TDPX2
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
---|---|---|---|
611151 | 25 µg | ¥26,400 | |
611152 | 100 µg | ¥83,600 |
Peroxiredoxin 1, also called PRDX1, is one of six members of the superfamily of thiol-dependent peroxidases. Peroxiredoxin 1 can eliminate reactive oxygen and nitrogen species. As a critical antioxidant enzyme, it utilizes an N-terminal cystine to detoxify peroxides and protect cells from oxidative stress damage. As a sensor of inflammation response, extracellular Peroxiredoxin 1 is released to trigger TLR4-dependent secretion of TNF-α and IL-6 in macrophage and dendritic cell maturation. Peroxiredoxin 1 is increased in bone marrow-derived macrophages by lipopolysaccharide (LPS) and IFN-γ exposure. In microglia, the expression level of Peroxiredoxin 1 is regulated through ROS/p38/MAPK pathway and protects microglia from cell death. Overexpression of Peroxiredoxin 1 in rat primary hippocampus neuronal and PC12 cells promotes survival under amyloid β toxicity. In addition to its role as an antioxidant, oxidized Peroxiredoxin 1 forms an oligomer that acts as a chaperone to suppress the c-Myc oncogene and promotes tumor cell apoptosis.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant protein of human Peroxiredoxin 1
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg/mL. For immunocytochemistry, a concentration of 5.0 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This product is not recommended for use in IHC-P.
For immunocytochemistry, fixation with ice-cold methanol is recommended.
- RRID
-
AB_2936735 (BioLegend Cat. No. 611151)
AB_2936735 (BioLegend Cat. No. 611152)
Antigen Details
- Structure
- Peroxiredoxin 1 is a 199 amino acid protein with an expected molecular weight of 22 kD. It exists as a homodimer and homodecamer.
- Distribution
-
Mainly expressed in cytoplasm; Distributed ubiquitously across tissues
- Function
- Catalyzes the reduction of hydrogen peroxide and organic hydroperoxides
- Interaction
- Peroxiredoxin 1, PTEN, Androgen receptor, C-ABL
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Death, Signal Transduction, Transcription Factors
- Antigen References
-
- Shau H, et al. 1993. Cell Immunol. 147:1-11.
- Wood ZA, et al. 2003. Trends Biochem. Sci. 28:32-40.
- Cumming RC, et al. 2007. J Biol Chem. 282:30523-34.
- Kim SU, et al. 2008. Biol Pharm Bull. 31:820-5.
- Gene ID
- 5052 View all products for this Gene ID
- UniProt
- View information about Peroxiredoxin 1 on UniProt.org
Related FAQs
Other Formats
View All Peroxiredoxin 1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Peroxiredoxin 1 | 6A6-4H3-7A3 | WB,ICC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
Follow Us