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- Clone
- WEN28 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- KLRC1, Killer Cell Lectin Like Receptor C1, KLRC2, Killer Cell Lectin Like Receptor C2, KLRC3, Killer Cell Lectin Like Receptor C3
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Rat splenocytes were stained with purified NKG2A/C/E (clone WEN28, top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG PE. The cells were then stained with anti-rat CD161 APC. -
The NKG2 molecules are a family of lectin-like receptors that form heterodimers with CD94. NKG2/CD94 heterodimer are primarily expressed on NK cells, and a subset of CD8+ T cells. Studies of CD94/NKG2 heterodimers on NK cells have demonstrated that the NKG2 components transduce signals after ligand binding. NKG2A transduces inhibitory signals, while NKG2C and NKG2E transduce activating signals.
Product DetailsProduct Details
- Verified Reactivity
- Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant rat NKG2A-Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
-
Application References
(PubMed link indicates BioLegend citation) -
- Sasther PC, et al, 2011, J Immunol, 187:6365
- RRID
-
AB_2716215 (BioLegend Cat. No. 250702)
Antigen Details
- Structure
- Type II transmembrane protein
- Distribution
-
NK cells, a subset of CD8+ T-lymphocytes.
- Function
- Signal transduction, Receptor for non-classical MHC Class I molecules
- Interaction
- DAP10, DAP12, CD94
- Ligand/Receptor
- Non-classical MHC Class I glycoproteins
- Cell Type
- NK cells, T cells
- Biology Area
- Immunology
- Molecular Family
- MHC Antigens
- Antigen References
-
- Berg SF, et al. 1998. Eur J Immunol, 28:444.
- Vance RE, et al. 1999. J Exp Med. 190(12).
- Vance RE, et al. 1998. J Exp Med. 188(10).
- Flornes LM, et al. 2010, Immunogenetics, 62:521
- Dissen E, et al. 2008. Semin Immunol. 20:369
- Gene ID
- 500338 View all products for this Gene ID 29683 View all products for this Gene ID 29684 View all products for this Gene ID
- UniProt
- View information about NKG2A on UniProt.org
Other Formats
View All NKG2A/C/E Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-rat NKG2A/C/E | WEN28 | FC |
| APC anti-rat NKG2A/C/E | WEN28 | FC |
| PE anti-rat NKG2A/C/E | WEN28 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-rat NKG2A/C/E
Rat splenocytes were stained with purified NKG2A/C/E (clone ... 
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APC anti-rat NKG2A/C/E
Rat splenocytes were stained with anti-rat NKG2A/C/E APC (cl... -
PE anti-rat NKG2A/C/E
Rat splenocytes were stained with anti-rat NKG2A/C/E PE (clo...
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