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- Clone
- SS1A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot analysis of extracts from Raw 264.7 cells starved for 20h (lane 1) and starved for 20h and treated with 1 µg/ml LPS for 9h (lane 2) using anti-RIG-1 antibody (clone SS1A).
RIG-1/DDX58(Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal forinnate antiviral responses including the production of typeI IFN. Clone SS1A has been shown to be useful for western blotting of the mouse RIG-1 protein.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Peptide-KLH, C-terminal end of murine RIG-1
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
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AB_940599 (BioLegend Cat. No. 635201)
Antigen Details
- Structure
- RIG-1 is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD.
- Distribution
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Cytoplasm.
- Function
- Involved in innate immune defense against viruses. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 is one of the key intracellular receptors that sense intracellular viral infection and trigger a signal for
- Interaction
- Cardif
- Biology Area
- Cell Biology, Transcription Factors
- Antigen References
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1. Imaizumi T, et al. 2002. Biochem. Biophys. Res. Commun. 292:274
2. Kato H, et al. 2006. Nature 441:101
3. Kato H, et al. 2005. Immunity 23:19 - Gene ID
- 109906 View all products for this Gene ID
- UniProt
- View information about RIG-1 on UniProt.org
Related FAQs
Other Formats
View All RIG-1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-RIG-1 | SS1A | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-RIG-1
Western blot analysis of extracts from Raw 264.7 cells starv...
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