- Clone
- BSB-49 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Tg
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Thyroglobulin (Tg) is a dimeric glycoprotein that is predominantly produced by follicular cells of the thyroid. This protein is secreted from the endoplasmic reticulum to the follicular lumen. Tg acts as a substrate for the synthesis of thyroxine (T4) and triiodothyronine (T3) as well as storage of inactive forms of thyroid hormone and iodine.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human thyroglobulin protein.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2629663 (BioLegend Cat. No. 846902)
Antigen Details
- Structure
- Thyroglobulin is a 2768 amino acid protein with a molecular mass of 305 kD.
- Distribution
-
Tissue distribution: thyroid.
Cellular distribution: extracellular, endoplasmic reticulum and plasma membrane. - Function
- Thyroglobulin is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
- Interaction
- HSPA5
- Biology Area
- Cell Biology, Neuroscience
- Molecular Family
- Hormones
- Antigen References
-
1. Ma ZF, Skeaff SA. 2014. Thyroid 24(8):1195-209. PubMed
2. Sellitti DF, Suzuki K. 2014. Thyroid 24(4):625. PubMed
3. Bellet D, et al. 1983. J. Clin. Endocrinol. Metab. 56:530. PubMed - Gene ID
- 7038 View all products for this Gene ID
- UniProt
- View information about Thyroglobulin on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Thyroglobulin Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Thyroglobulin | BSB-49 | IHC-P |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-Thyroglobulin
IHC staining of purified anti-Thyroglobulin antibody (clone ...
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