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- Clone
- M2004D03 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Erythroid-potentiating activity (EPA), Fibroblast collagenase inhibitor, Tissue inhibitor of metalloproteinases 1 (TIMP1)
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot analysis of 50ng recombinant human TIMP-1 (lane 1, Cat. No. 592402), and recombinant mouse TIMP-1 (lane 2, Cat. No. 593702) using anti-TIMP-1 antibody (clone M2004D03) and HRP anti-mouse IgG antibody (Cat. No. 405306).
TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that is well recognized for its role in extracellular matrix remodeling through controlling the activity of matrix metalloproteinases (MMPs). Independent of MMP inhibition, TIMPs also act as signaling molecules and plays important roles in cell growth, apoptosis, differentiation, angiogenesis, and oncogenesis. High level of TIMP-1 protein has been found in several types of cancers and associated with a poor patient prognosis. TIMP-1 may be useful as a cancer prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1).
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human TIMP-1.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- Affinity purified.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2565609 (BioLegend Cat. No. 676002)
Antigen Details
- Structure
- Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD.
- Distribution
-
Widely expressed in mammalian tissues, notably in reproductive organs.
- Function
- TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes.
- Interaction
- MMP-1, MMP-3, MMP-9.
- Ligand/Receptor
- CD63.
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
1. Brew K and Nagase H. 2010. Biochim. Biophys. Acta. 1803:55.
2. Murphy G. 2011. Genome Biol. 12:233.
3. Bourboulia D and Stetler-Stevenson WG. 2010. Semin. Cancer Biol. 20:161.
4. Kim YS, et al. 2012. BMB Rep. 45:623.
5. Ries C. 2014. Cell Mol. Life Sci. 71:659. - Gene ID
- 30949 View all products for this Gene ID
- UniProt
- View information about TIMP-1 on UniProt.org
Other Formats
View All TIMP-1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-TIMP-1 | M2004D03 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-TIMP-1
Western blot analysis of 50ng recombinant human TIMP-1 (lane...
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