Loading...

APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
Cat # Size Price Save
123115 25 µg ¥11,000
123116 100 µg ¥31,460
Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  2. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  3. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  4. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  5. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  6. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  7. Yang D, et al. 2022. Cell. 185:1905. PubMed
  8. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  9. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  10. Nesseler JP, et al. 2020. Cancers (Basel). 12: . PubMed
  11. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  12. Fang C, et al. 2022. J Pathol. 256:310. PubMed
  13. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  14. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  15. Yousefi M, et al. 2022. Cancer Res. 82:1589. PubMed
  16. Chen J, et al. 2022. Adv Sci (Weinh). 9:e2200668. PubMed
  17. Sipilä K, et al. 2022. Dev Cell. 57:1453. PubMed
  18. Jang HJ, et al. 2022. Cancer Res. 82:2593. PubMed
  19. Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed
  20. Xu J, et al. 2022. Invest Ophthalmol Vis Sci. 63:15. PubMed
  21. Schaue D, et al. 2022. Antioxidants (Basel). 11: . PubMed
  22. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  23. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  24. Yoo HJ, et al. 2022. Cell Rep. 41:111598. PubMed
  25. Nagre N, et al. 2022. Respir Res. 23:326. PubMed
  26. Miao Y, et al. 2022. Front Pharmacol. 13:1032741. PubMed
  27. Kuo CS, et al. 2022. Elife. 11: . PubMed
  28. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  29. Wang R, et al. 2023. Nat Biomed Eng. 7:38. PubMed
  30. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  31. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  32. Wang Y, et al. 2023. FASEB J. 37:e22776. PubMed
  33. Fontana MF, et al. 2023. Elife. 12: . PubMed
  34. Kulkarni R, et al. 2023. Life Sci Alliance. 6: . PubMed
  35. Slusarczyk P, et al. 2023. Elife. 12: . PubMed
  36. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  37. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  38. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  39. Li FJ, et al. 2022. Am J Physiol Lung Cell Mol Physiol. 322:L593. PubMed
  40. Kraynak CA, et al. 2022. Int J Pharm. 618:121634. PubMed
  41. Fernández-García V, et al. 2022. Biomed Pharmacother. 148:112769. PubMed
  42. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  43. Quattrocelli M, et al. 2022. J Exp Med. 219:. PubMed
  44. Hailemichael Y, et al. 2022. Cancer Cell. 40:509. PubMed
  45. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  46. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  47. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  48. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  49. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  50. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  51. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  52. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  53. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  54. Czimmerer Z, et al. 2022. Immunity. 55:2006. PubMed
  55. Amodio V, et al. 2023. Cancer Cell. 41:196. PubMed
  56. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  57. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  58. Liu PS, et al. 2023. Nat Immunol. 24:452. PubMed
  59. Mizutani T, et al. 2023. iScience. 26:106081. PubMed
  60. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  61. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  62. Wang Y, et al. 2023. EBioMedicine. 90:104480. PubMed
  63. Tan J, et al. 2023. Acta Pharm Sin B. 13:632. PubMed
  64. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  65. Zhu S, et al. 2023. J Nanobiotechnology. 21:81. PubMed
  66. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  67. He XY, et al. 2023. Nat Commun. 14:2253. PubMed
  68. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  69. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  70. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  71. Shen Z, et al. 2023. iScience. 26:106572. PubMed
  72. Ji Y, et al. 2023. Nat Cell Biol. 25:726. PubMed
  73. He Y, et al. 2023. Biomolecules. 13:. PubMed
  74. Wang C, et al. 2023. Int J Oral Sci. 15:19. PubMed
  75. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  76. Song S, et al. 2023. Bioact Mater. 28:358. PubMed
  77. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  78. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  79. He R, et al. 2021. J Immunol. 206:2353. PubMed
  80. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  81. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  82. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  83. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  84. He F, et al. 2021. J Exp Med. 218:. PubMed
  85. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  86. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  87. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  88. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  89. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  90. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  91. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  92. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  93. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  94. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  95. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  96. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  97. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  98. Kim SE, et al. 2019. Nutrients. 11. PubMed
  99. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  100. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  101. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  102. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  103. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  104. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  105. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  106. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  107. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  108. Dong L, et al. 2021. Cancer Cell. . PubMed
  109. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  110. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  111. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  112. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  113. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  114. Han J, et al. 2022. FEBS J. 289:417. PubMed
  115. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  116. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  117. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  118. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  119. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  120. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  121. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  122. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  123. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  124. Sun P, et al. 2015. J Hepatol. . PubMed
  125. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  126. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  127. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  128. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  129. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  130. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  131. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  132. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  133. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  134. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  135. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  136. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  137. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  138. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  139. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  140. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  141. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  142. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  143. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  144. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  145. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  146. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  147. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  148. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  149. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  150. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  151. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  152. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  153. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  154. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  155. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  156. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  157. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  158. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  159. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  160. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  161. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  162. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  163. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  164. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  165. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  166. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  167. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  168. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  169. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  170. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  171. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  172. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  173. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  174. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  175. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  176. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  177. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  178. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  179. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  180. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  181. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  182. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  183. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  184. Lv F, et al. 2022. iScience. 25:103639. PubMed
  185. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  186. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  187. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  188. Gao H, et al. 2021. Cells. 10:. PubMed
  189. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  190. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  191. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  192. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  193. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  194. Oatley J, et al. 2009. Development. 136:1191. PubMed
  195. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  196. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  197. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  198. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  199. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  200. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  201. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  202. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  203. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  204. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  205. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  206. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  207. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  208. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  209. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  210. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  211. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  212. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  213. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  214. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  215. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  216. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  217. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  218. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  219. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  220. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  221. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  222. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  223. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  224. Yang Y, et al. 2022. Elife. 11:. PubMed
  225. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  226. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  227. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  228. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  229. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  230. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  231. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  232. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  233. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  234. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  235. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  236. Matundan H, et al. 2019. J Virol. 93. PubMed
  237. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  238. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  239. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  240. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  241. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  242. Lang V, et al. 2021. Elife. 10:. PubMed
  243. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  244. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  245. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  246. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  247. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  248. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  249. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  250. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  251. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  252. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  253. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  254. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  255. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  256. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  257. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  258. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  259. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  260. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  261. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  262. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  263. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  264. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  265. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  266. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  267. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  268. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  269. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  270. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  271. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  272. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  273. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  274. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  275. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  276. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  277. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  278. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  279. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  280. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  281. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  282. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  283. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  284. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  285. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  286. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  287. Calle P, et al. 2021. Cells. 10:. PubMed
  288. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  289. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  290. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  291. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  292. Deng W, et al. 2015. Clin Immunol. . PubMed
  293. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  294. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  295. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  296. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  297. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  298. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  299. Engblom C, et al. 2017. Science. 358:6367. PubMed
  300. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  301. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  302. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  303. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  304. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  305. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  306. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  307. Horsle B 2013. Development. 140:1517. PubMed
  308. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  309. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  310. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  311. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  312. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  313. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  314. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  315. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  316. Karki R, et al. 2020. bioRxiv. . PubMed
  317. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  318. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  319. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  320. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  321. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  322. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  323. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  324. Gu H, et al. 2021. Elife. 10:. PubMed
  325. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  326. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  327. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  328. Karki R, et al. 2021. Cell. 184:149. PubMed
  329. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  330. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  331. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  332. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  333. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  334. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  335. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  336. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  337. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  338. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  339. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  340. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  341. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  342. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  343. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  344. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  345. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  346. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  347. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  348. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  349. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  350. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  351. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  352. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  353. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  354. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  355. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  356. Liu SS, et al. 2021. Immunity. :. PubMed
  357. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  358. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  359. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  360. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  361. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  362. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  363. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  364. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  365. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  366. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  367. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  368. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  369. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  370. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  371. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  372. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  373. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  374. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  375. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  376. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  377. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  378. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  379. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  380. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  381. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  382. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  383. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  384. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  385. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  386. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  387. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  388. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  389. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  390. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  391. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
  392. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  393. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  394. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  395. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
  396. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  397. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  398. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  399. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  400. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  401. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  402. Lalor R, et al. 2019. Nutrients. 11. PubMed
RRID
AB_893481 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark Red™ 718 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Spark Blue™ 574 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account