- Clone
- 58A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- MPZ, Myelin Protein Zero
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![58A_A488_MPZ_Antibody_1_072519 58A_A488_MPZ_Antibody_1_072519](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/58A_A488_MPZ_Antibody_1_072519.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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IHC staining of Alexa Fluor® 488 anti-Myelin Protein Zero antibody (clone 58A) on formalin-fixed paraffin-embedded rat sciatic nerve tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 2 µg/ml of the primary antibody overnight at 4°C. The slide was mounted with Fluoromount-G™, with DAPI. The image was captured with a 40X objective. Scale Bar: 50 µm -
IHC staining of Alexa Fluor® 488 anti-Myelin Protein Zero antibody (clone 58A) on formalin-fixed paraffin-embedded mouse sciatic nerve tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 2 µg/ml of the primary antibody overnight at 4°C. The slide was mounted with Fluoromount-G™, with DAPI. The image was captured with a 40X objective. Scale Bar: 50 µm
Cat # | Size | Price | Quantity Check Availability | Save | ||
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862207 | 25 µg | 123€ | ||||
862208 | 100 µg | 259€ |
Myelin protein zero (MPZ), is a membrane glycoprotein mainly expressed in the peripheral nervous system (PNS). It is the major structural component of the myelin sheath, and accounts for at least 50% of all proteins in the PNS. MPZ is expressed by Schewann cells. Mutations in MPZ have been associated with myelin deficiency, which may lead to neuropathies including charcot-Marie-Tooth and Dejerine-Sottas diseases.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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IHC-P - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Application References
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- Yoshimura K, et al. 1996. Neurosci Res. 25(1):41 (WB, IHC, ELISA)
- RRID
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AB_2814591 (BioLegend Cat. No. 862207)
AB_2814592 (BioLegend Cat. No. 862208)
Antigen Details
- Structure
- MPZ is a 248 amino acid protein with an apparent molecular mass of ~ 28 kD.
- Distribution
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Tissue Distribution: Peripheral nervous system
Cellular Distribution: Plasma membrane, extracellular, endoplasmic reticulum, and lysosome - Function
- MPZ is an adhesion molecule involved in the formation of myelin sheath in the peripheral nervous system.
- Interaction
- Forms homodimer and homotetramer
- Biology Area
- Neurodegeneration, Neuroscience Cell Markers
- Molecular Family
- Adhesion Molecules
- Antigen References
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- Chiò A and Lauria G. 2016. Lancet Neurol. 15(1):12
- Brennan KM, et al. 2015. Neurosci Lett. 596:14
- Tazir M, et al. 2014. J Neurol Sci. 347(1-2):14
- Gene ID
- 4359 View all products for this Gene ID 17528 View all products for this Gene ID 24564 View all products for this Gene ID
- UniProt
- View information about Myelin Protein Zero on UniProt.org
Related FAQs
Other Formats
View All Myelin Protein Zero Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Myelin Protein Zero | 58A | IHC-P,WB |
Biotin anti-Myelin Protein Zero | 58A | IHC-P |
Alexa Fluor® 647 anti-Myelin Protein Zero | 58A | IHC-P |
Alexa Fluor® 488 anti-Myelin Protein Zero | 58A | IHC-P |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-Myelin Protein Zero
Western blot of purified anti-Myelin Protein Zero antibody (... IHC staining of purified anti-Myelin Protein Zero antibody (... IHC staining of purified anti-Myelin Protein Zero antibody (... IHC staining of purified anti-Myelin Protein Zero antibody (... -
Biotin anti-Myelin Protein Zero
IHC staining of anti-Myelin Protein Zero (clone 58A) on form... IHC staining of anti-Myelin Protein Zero (clone 58A) on form... -
Alexa Fluor® 647 anti-Myelin Protein Zero
IHC staining of Alexa Fluor® 647 anti-Myelin Protein Zero an... IHC staining of Alexa Fluor® 647 anti-Myelin Protein Zero an... -
Alexa Fluor® 488 anti-Myelin Protein Zero
IHC staining of Alexa Fluor® 488 anti-Myelin Protein Zero an... IHC staining of Alexa Fluor® 488 anti-Myelin Protein Zero an...
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