- Clone
- 1-10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD26, Adenosine deaminase binding protein (ADABP), Adenosine deaminase complex
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
628153 | 50 µg | 396€ |
Dipeptidyl peptidase IV (DPP4) is a multifunctional type II transmembrane serine peptidase. It is also known as a cell surface glycoprotein receptor, CD26, involved in the co-stimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. It acts as a positive regulator of T-cell co-activation, by binding at least ADA, CAV1, IGF2R, and PTPRC. DPP4 is widely expressed in many specialized cell types and has distinct functions independently of its form, anchored to the membrane or in soluble form. The soluble form of DPP4 appears to be derived primarily from endothelial cells, epithelial cells, and leukocytes. It is upregulated in proinflammatory states including obesity, type-2 diabetes mellitus, and atherosclerosis. DPP4 is a serine aminopeptidase that cleaves preferentially Xaa–Pro dipeptides from oligopeptides with typical length of 30 amino acid, but tolerates other small residues at P1-position. Its biological substrates include many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Thus, it regulates various physiological processes by cleaving peptides in the circulation on the cell surface. It has been discovered that DPP4 may be a receptor for receptor binding domain (RBD) of spike entry glycoprotein in Middle East respiratory syndrome coronavirus (MERS-CoV).
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Recombinant DDP4 Protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
Direct ELISA - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.
- Additional Product Notes
-
This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone 1-10) could function as a detection antibody when paired with purified anti-human CD26 (DDP4) (Cat. No. TBD) (clone 5-109) as the capture antibody and using Recombinant Human DDP4 (carrier-free) protein (Cat. Nos. 764102, 764104, and 764106) as the assay standard.
- RRID
-
AB_3106020 (BioLegend Cat. No. 628153)
Antigen Details
- Distribution
-
High expression in RPTEC/TERT1, BJ-hTERT, and ASC-TERT1 cell line; moderate expression in PC-3 and Hep G2 cell line
- Interaction
- T-Cell, lymphocyte
- Ligand/Receptor
- Adenosin deaminase (ADA), RANTES, stromal cell-derived factor (SDF)-1α, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1)
- Cell Type
- Embryonic Stem Cells
- Biology Area
- Angiogenesis, Cell Biology, Stem Cells
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
- Metzemaekers M, et al. 2016. Front in Immunology. 7:483.
- Song W, et al.2014. Virology. 473:49-53.
- Ohnuma K, et al 2007. J Biol Chem. 282:10117-10131.
- Engel M, et al. 2003. PNAS USA. 100:5063.
- Morimoto C, et al. 1989. J Immunol. 143:3430-9.
- Gene ID
- 1803 View all products for this Gene ID
- UniProt
- View information about CD26 on UniProt.org
Related FAQs
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Other Formats
View All CD26 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Biotin anti-human CD26 (DDP4) | 1-10 | Direct ELISA |
Purified anti-human CD26 (DDP4) | 1-10 | Direct ELISA |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Biotin anti-human CD26 (DDP4)
Direct ELISA showing biotin anti-human CD26 (DDP4) antibody ... -
Purified anti-human CD26 (DDP4)
Direct ELISA showing purified anti-human CD26 (DDP4) (clone ...
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