- Clone
- p282 (H19) (See other available formats)
- Regulatory Status
- RUO
- Workshop
- V S006
- Other Names
- Protectin, H19, 1F-5Ag, HRF20, MACIF, MIRL, P-18
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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304706 | 100 tests | 181€ |
CD59 is a 19-25 kD glycosylphosphatidylinositol (GPI)-anchored glycoprotein also known as protectin, MACIF, and H19. It is broadly expressed on hematopoietic and non-hematopoietic cells. CD59 inhibits the cytolytic activity of complement by binding to C9, inhibiting incorporation into C5b-8, and preventing the terminal steps in complement polymerization of the membrane attack complex. CD59 has also been reported to play a role in T cell activation.
Product DetailsProduct Details
- Verified Reactivity
- Human, Cynomolgus, Rhesus
- Reported Reactivity
- Baboon, Chimpanzee
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Application References
-
- Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
- Product Citations
-
- RRID
-
AB_2076126 (BioLegend Cat. No. 304706)
Antigen Details
- Structure
- Ly6 superfamily, single chain GPI-linked membrane protein, 19-25 kD
- Distribution
-
All cell types
- Function
- Blocks complement-mediated lysis by inhibiting MAC formation
- Ligand/Receptor
- Complement components C8, C9
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules
- Antigen References
-
1. Davies A, et al. 1993. Immunol. Res. 12:258.
2. Lachmann P. 1991. Immunol. Today 12:312.
3. Liszewski M, et al. 1996. Adv. Immunol. 61:201. - Gene ID
- 966 View all products for this Gene ID
- UniProt
- View information about CD59 on UniProt.org
Related FAQs
Other Formats
View All CD59 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
FITC anti-human CD59 | p282 (H19) | FC |
PE anti-human CD59 | p282 (H19) | FC |
Purified anti-human CD59 | p282 (H19) | FC |
TotalSeq™-A0361 anti-human CD59 | p282 (H19) | PG |
APC anti-human CD59 | p282 (H19) | FC |
TotalSeq™-B0361 anti-human CD59 | p282 (H19) | PG |
TotalSeq™-C0361 anti-human CD59 | p282 (H19) | PG |
TotalSeq™-D0361 anti-human CD59 | p282 (H19) | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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FITC anti-human CD59
Human peripheral blood lymphocytes stained with p282(H19) FI... -
PE anti-human CD59
Human peripheral blood lymphocytes stained with p282 PE Pre-lysed human blood leukocytes were stained with CD59 (clo... -
Purified anti-human CD59
Human peripheral blood lymphocytes stained with purified p28... -
TotalSeq™-A0361 anti-human CD59
-
APC anti-human CD59
Human peripheral blood lymphocytes were stained with anti-hu... -
TotalSeq™-B0361 anti-human CD59
-
TotalSeq™-C0361 anti-human CD59
-
TotalSeq™-D0361 anti-human CD59
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