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PE anti-human CD262 (DR5, TRAIL-R2) Antibody

Pricing & Availability
Clone
DJR2-4 (7-8) (See other available formats)
Regulatory Status
RUO
Workshop
HCDM listed
Other Names
TRAIL-R2, KILLER, TRICK2, TNFRSF10B, Ly98, CD262
Isotype
Mouse IgG1, κ
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Product Citations
publications
DJR2-4_PE_072007
Human DR5 transfected cells stained with DJR2-4 PE
  • DJR2-4_PE_072007
    Human DR5 transfected cells stained with DJR2-4 PE
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307405 25 tests 108€
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307406 100 tests 244€
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Description

DR5 is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B), also known as TRAIL-R2, TRICK2, KILLER, and CD262. It binds the cytotoxic ligand TRAIL and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Extracellular domain of DR5-human IgG1 Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References
  1. Uno K, et al. 2003. Blood 101:3658.
  2. Sato K, et al. 2005. J. Immunol. 174:4025.
  3. Lundgvist A,et al.2006.Cancer Res.14:7317.PubMed
Product Citations
  1. Braun F, et al. 2015. PLoS One. 10:117994. PubMed
  2. Cox MJ, et al. 2022. Leukemia. 36:1635. PubMed
  3. Lin CP, et al. 2023. EMBO J. 42:e111614. PubMed
  4. Grayson KA, et al. 2021. Mol Cancer Ther. 20:833. PubMed
  5. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  6. Ng W, et al. 2021. Pharm Biol. 59:47:00. PubMed
  7. Yerbes R, et al. 2022. Cell Death Dis. 13:906. PubMed
  8. Vunnam N, et al. 2017. Biophys J. 10.1016/j.bpj.2017.05.038. PubMed
  9. Wu Y, et al. 2019. Sci Rep. 9:20301. PubMed
  10. Bernareggi D, et al. 2022. Nat Commun. 13:1899. PubMed
  11. Magnussen G, et al. 2012. Biochem Biophys Res Commun. 420:516. PubMed
  12. Grayson KA, et al. 2021. PLoS One. 16:e0246733. PubMed
  13. Greenlee JD, et al. 2021. eLife. 0.416666666666667. PubMed
  14. Volpin V, et al. 2020. Cancer Immunol Res. 8:1163. PubMed
  15. Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
  16. Ray JE, et al. 2021. Cancer Biol Ther. 22:554. PubMed
  17. Kolluri KK et al. 2018. eLife. 7 pii: e30224. PubMed
  18. Brin E, et al. 2018. Oncotarget. 9:36914. PubMed
  19. Stolfi C, et al. 2011. Mol Cancer Ther. 1.159027778. PubMed
  20. Choi Y, et al. 2015. Gut. 64: 1303-1313. PubMed
  21. Ishii Y, et al. 2021. J Biol Chem. 297:101223. PubMed
  22. Canestraro M, et al. 2010. Cancer Genet Cytogenet. 199:110. PubMed
RRID
AB_2204926 (BioLegend Cat. No. 307405)
AB_2204926 (BioLegend Cat. No. 307406)

Antigen Details

Structure
TNFR superfamily, 55 kD
Distribution

Broadly expressed on normal and tumor cells

Function
Induces apoptosis
Ligand/Receptor
TRAIL
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. MacFarlane M, et al. 1997. J. Biol. Chem. 272:25417.
2. Walczak H, et al. 1997. EMBO J. 16:5386.
3. Shigeno M, et al. 2003. Oncogene 22:1653.
4. LaVallee T, et al. 2003. Cancer Res. 63:468.
5. Nimmanapalli R, et al. 2001. Cancer Res. 61:759

Gene ID
8795 View all products for this Gene ID
UniProt
View information about CD262 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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