- Clone
- W17230A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Growth Factor Receptor Bound Protein 2, SH2/SH3 Adaptor Protein GRB2, ASH, Epidermal Growth Factor Receptor-Binding Protein GRB2, Abundant SRC Homology, MSTP084, Grb3-3, MST084, NCKAP2
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
627001 | 25 µg | 81€ | ||||
627002 | 100 µg | 203€ |
GRB2 is a receptor tyrosine kinase (RTK) adaptor protein that transduces signaling cascades from activated receptors. Upon receptor stimulation, GRB2 binds phosphorylated RTK tyrosine residues via a central SH2 domain; flanking GRB2 SH3 domains facilitate the recruitment of downstream effectors to the activated RTK.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Synthetic peptide corresponding to amino acid residues 199-214 of human GRB2.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone has not been tested for ICC or IP.
- RRID
-
AB_2810687 (BioLegend Cat. No. 627001)
AB_2810687 (BioLegend Cat. No. 627002)
Antigen Details
- Structure
- GRB2 is a 217 amino acid protein with a predicted molecular weight of 25 kD.
- Distribution
-
Plasma membrane-associated/ubiquitously expressed
- Function
- Adaptor protein in RTK signaling pathways
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Adaptor Proteins, Phospho-Proteins
- Antigen References
-
- Lowenstein EJ, et al. 1992. Cell. 70:431-42.
- Matuoka K, et al. 1992. Proc Natl Acad Sci U S A. 89:9015-9.
- Skolnik EY, et al. 1993. Science. 260:1953-5.
- Pendergast AM, et al. 1993. Cell. 75:175-85.
- Gene ID
- 2885 View all products for this Gene ID
- UniProt
- View information about GRB2 on UniProt.org
Other Formats
View All GRB2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-GRB2 | W17230A | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-GRB2
Whole cell extracts (15 µg protein) from the indicated cell ...
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