- Clone
- A18192B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Homer protein homolog 1 (HOMER1), SYN47
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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610551 | 25 µg | 96€ | ||||
610552 | 100 µg | 300€ |
HOMER1 is a scaffolding protein that is a major component of the post-synaptic density (PSD), a region in the plasma membrane of the post-synaptic neuron that interacts with the pre-synaptic active zone of upstream neurons. HOMER1 consists of two domains, a C-terminal coiled-coil domain that is required for HOMER1 dimerization, and an EVH1 domain involved in protein-protein interaction. Dimerized long-form HOMER1 (variants designated as Homer1b and Homer1c) is constitutively expressed in neurons, where it plays a role in neurotransmitter receptor signaling and trafficking by cross-linking associated proteins via the EVH1 domain. Truncated HOMER1 (Homer1a) is expressed as a result of neuronal activity, and lacking the coiled-coil domain, is incapable of dimerizing and cannot crosslink interacting proteins. Thus, Homer1a acts as a dominant-negative regulator of HOMER1 and is thought to provide negative feedback against excessive neuronal activity.
Product DetailsProduct Details
- Verified Reactivity
- Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human HOMER1
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 0.5 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This product is not recommended for use in Immunohistochemistry.
This product does not recognize mouse or human HOMER1 in Western Blot.
This product only recognizes full length HOMER1 (Homer1b/c) and not the truncated variant Homer1a. - RRID
-
AB_2936737 (BioLegend Cat. No. 610551)
AB_2936737 (BioLegend Cat. No. 610552)
Antigen Details
- Structure
- HOMER1 is a 354 amino acid protein with a predicted molecular weight of 40 kD.
- Distribution
-
Post-synaptic density
- Function
- Protein-protein interactions, synaptic plasticity
- Interaction
- Homodimer; also interacts with other major components of the PSD including Shank family proteins, cytoskeletal proteins like dynamin, and receptors such as group 1 metabotropic glutamate receptors and the ryanodine receptor.
- Cell Type
- Mature Neurons, Neurons
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Signal Transduction, Synaptic Biology
- Molecular Family
- Postsynaptic proteins, Scaffold Proteins
- Antigen References
-
- Foa L, et al. 2001. Nat Neurosci. 4:499-506.
- de Bartolomeis A, et al. 2022. Neurosci Biobehav Rev. 136:104596.
- Salanova M, et al. 2013. IUBMB Life. 65:769-76.
- Reshetnikov VV, et al. 2021. Biochemistry (Mosc). 86:613-626.
- Gene ID
- 9456 View all products for this Gene ID
- UniProt
- View information about HOMER1 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All HOMER1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-HOMER1 | A18192B | WB |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-HOMER1
Whole cell extracts (15 µg total protein) from the indicated...
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