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- Clone
- S23004D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD158d, Killer Cell Immunoglobulin-Like Receptor 2DL4, KIR103AS
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with purified anti-human CD158d (KIR2DL4) (clone S23004D) (left) or purified mouse IgG1, κ isotype control (right), followed by goat anti-mouse IgG PE. Cells were costained with anti-human CD56 (clone QA17A16) APC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 335406 | 100 µg | 280€ | ||||
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIMs and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.
CD158d is a glycoprotein with two extracellular Ig domain and a long cytoplasmic tail with an ITIM motif. It is expressed primarily on CD56-high and activated NK cells. KIR2DL4 has been reported to bind to the non-classical MHC class I molecule HLA-G.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- KIR2DL4-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone S23004D may increase the binding of clone mAb 33 on target cells.
Based on in-house testing on different KIR-expressing transfectants, clone S23004D does not interact with other KIR protein family members.
Antigen Details
- Structure
- Two Ig-like extracellular domain glycoprotein
- Function
- NK cell regulation
- Ligand/Receptor
- HLA-G
- Cell Type
- NK cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
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- Vilches C, et al. 2002. Annu Rev Immunol. 92.107361.
- Middleton D, et al. 2010. Immunol. 123:8.
- Zheng G, et al. 2021. Sig Transduct Target Ther. 6.236.
- Gene ID
- 3805 View all products for this Gene ID
- UniProt
- View information about CD158d on UniProt.org
Related FAQs
Other Formats
View All CD158d Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD158d (KIR2DL4) Antibody | S23004D | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD158d (KIR2DL4) Antibody
Human peripheral blood lymphocytes were stained with purifie...
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