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Purified anti-human CD161 Antibody

Pricing & Availability
Clone
HP-3G10 (See other available formats)
Regulatory Status
RUO
Other Names
NKR-P1A
Isotype
Mouse IgG1, κ
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Product Citations
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339902 100 µg 102€
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Description

CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human NK cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
WB - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: inhibition of cytokine production and Western blotting under nonreducing conditions.

Application References
  1. Gumß M, et al. 2004. Blood 104:3664.
  2. Exley M, et al. 1998. J. Exp. Med. 188:867.
  3. Marquez C, et al. 1998. Blood 91:2760.
Product Citations
  1. Rouers A, et al. 2021. Cell Rep Med. 2:100278. PubMed
  2. Feyaerts D, et al. 2022. Cell Rep Med. 3:100680. PubMed
  3. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  4. Volchenkov R, et al. 2017. Front Immunol. 0.818055556. PubMed
  5. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  6. Gruber CN, et al. 2020. Cell. 183:982. PubMed
  7. Niu C, et al. 2021. Front Immunol. 12:658562. PubMed
  8. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  9. Sattler A, et al. 2021. Am J Transplant. 21:87. PubMed
  10. Marrero I, et al. 2020. Alcohol Clin Exp Res. 44:1061. PubMed
  11. Chng MHY, et al. 2020. Immunity. 51(6):1119-1135.e5.. PubMed
  12. Ardain A, et al. 2019. Nature. 570:528. PubMed
  13. Cardoso V, et al. 2017. Nature. 549:277. PubMed
  14. Schwabenland M, et al. 2021. Immunity. . PubMed
  15. NULL, et al. 2022. Cell. 185:916. PubMed
  16. Mathewson ND, et al. 2021. Cell. 184(5):1281-1298.e26. PubMed
  17. Martin E, et al. 2020. JCI Insight. :5. PubMed
  18. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
RRID
AB_1501090 (BioLegend Cat. No. 339902)

Antigen Details

Structure
Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily
Distribution

NK cells, T subset, subset of CD3+ thymocytes

Ligand/Receptor
LLT-1 (Lectin-like transcript-1)
Cell Type
NK cells, T cells, Thymocytes
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Takahashi T, et al. 2006. J. Immunol. 176:211.
2. Cosmi L, et al. 2008. J. Exp. Med. 205:1903.
3. Aldemir H, et al. 2005. J. Immunol. 175:7791.
4. Rosen DB, et al. 2008. J. Immunol. 180:6508.

Gene ID
3820 View all products for this Gene ID
UniProt
View information about CD161 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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