- Clone
- 8F9 (See other available formats)
- Regulatory Status
- RUO
- Workshop
- HCDM listed
- Other Names
- C-type lectin family member 9A, CD370
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
353802 | 100 µg | 165€ |
CD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the transmembrane domain by a stalk region, and an intracellular cytoplasmic tail with immunoreceptor tyrosine-based activation motif (ITAM). In humans, CLEC9A is strictly expressed on BDCA3-positive conventional dendritic cells (cDC) and CD16- monocytes. CLEC9A recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_10983070 (BioLegend Cat. No. 353802)
Antigen Details
- Structure
- Type II transmembrane glycoprotein; consists of a 35 amino acid (aa) cytoplasmic domain with an ITAM like motif, a 21 aa transmembrane segment, a 185 aa extracellular domain (ECD) that contains a stalk region, and one C-type lectin domain (CTLD).
- Distribution
-
Dendritic subsets including plasmacytoid dendritic cells.
- Function
- Cross-present antigen to CTL, phagocytosis necrotic cells.
- Interaction
- Necrotic cells.
- Ligand/Receptor
- Ubiquitous preformed acid-labile protein associated ligand(s).
- Cell Type
- Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, MHC Antigens
- Antigen References
-
1. Poulin LF, et al. 2010. J. Exp. Med. 207:1261.
2. Sancho D, et al. 2009. Nature 458:899.
3. Huysamen C, et al. 2008. J. Biol. Chem. 283:16693. - Gene ID
- 283420 View all products for this Gene ID
- UniProt
- View information about CD370 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CD370 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD370 (CLEC9A/DNGR1) | 8F9 | FC |
PE anti-human CD370 (CLEC9A/DNGR1) | 8F9 | FC |
APC anti-human CD370 (CLEC9A/DNGR1) | 8F9 | FC |
TotalSeq™-A0207 anti-human CD370 (CLEC9A/DNGR1) | 8F9 | PG |
TotalSeq™-C0207 anti-human CD370 (CLEC9A/DNGR1) | 8F9 | PG |
TotalSeq™-B0207 anti-human CD370 (CLEC9A/DNGR1) | 8F9 | PG |
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