- Clone
- 4C3 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TM7XN1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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391902 | 100 µg | 231€ |
GPR56, also known as TM7XN1, is an orphan G-protein-coupled receptor (GPCR) containing seven transmembrane domains and a mucin-like domain in the N-terminal region. The total length of the human GPR56 gene is approximately 15 kb, and it consists of 13 exons and encodes 693 amino acids. GPR56 is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. Mutations in human GPR56 gene were found to cause a specific brain malformation called bilateral frontoparietal polymicrogyria. Recently, GPR56 was found specifically expressed on cytotoxic NK and T lymphocytes, including CD8+, CD4+, and γδ T cells, which might affect the migratory properties of these cells. GPR56 was also found significantly downregulated in some cancer cells, suggesting that it may play a role in growth suppression and cancer metastasis.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human GPR56 extracellular domain, complete Freund’s adjuvant, incomplete Freund’s adjuvant
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
Blocking, Direct ELISA, IP - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Additional reported applications (for the relevant formats) include: blocking the cell migration (1).
- Application References
-
- Ohta S, et al. 2015. Biol. Pharm. Bull. 38:594.
- RRID
-
AB_2687290 (BioLegend Cat. No. 391902)
Antigen Details
- Structure
- Contains seven transmembrane domains and a mucin-like domain in the N-terminal region.
- Distribution
-
T cells, NK cells, wide range of tissues such as brain, thyroid gland, and heart.
- Function
- May be involved in immune cell migration, cancer cell growth metastasis, and neuron development.
- Cell Type
- T cells, NK cells
- Antigen References
-
1. Peng YM, et al. 2011. J. Leuko. Biol. 90:735.
2. Shashidhar S, et al. 2005. Oncogene 24:1673.
3. Piao X, et al. 2004. Science 303:2033.
4. Liu M, et al. 1999. Genomics 55:296. - Gene ID
- 9289 View all products for this Gene ID
- UniProt
- View information about GPR56 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All GPR56 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human GPR56 | 4C3 | FC,Block,Direct ELISA,IP |
APC anti-human GPR56 | 4C3 | FC |
PE anti-human GPR56 | 4C3 | FC |
TotalSeq™-C1021 anti-human GPR56 | 4C3 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human GPR56
Human peripheral blood lymphocytes were stained with CD56 Pa... -
APC anti-human GPR56
Human peripheral blood lymphocytes were stained with CD56 PE... -
PE anti-human GPR56
Human peripheral blood lymphocytes were stained with CD56 PE... -
TotalSeq™-C1021 anti-human GPR56
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