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Purified anti-mouse CD38 Antibody

Pricing & Availability
Clone
90 (See other available formats)
Regulatory Status
RUO
Other Names
T10
Isotype
Rat IgG2a, κ
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Product Citations
publications
90_Pure_071608.jpg
C57BL/6 splenocytes stained with purified 90, followed by anti-rat IgG FITC
  • 90_Pure_071608.jpg
    C57BL/6 splenocytes stained with purified 90, followed by anti-rat IgG FITC
  • 90_Pure_CD38_Antibody_2_102518
    Fresh, frozen mouse spleen was stained with purified CD38 clone 90 conjugated and detected with a Cy3 CODEX™ oligonucleotide duplex (red). Samples were counterstained with B220 A647 (green). Data generated at Akoya Biosciences, Inc. using the CODEX™ technology.
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102702 500 µg 221€
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow pre-B cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Avalos A, et al. 2022. JCI Insight. 7: . PubMed
  2. Chang CY, et al. 2022. Sci Adv. 8:eabq0615. PubMed
  3. Niss Arfelt K, et al. 2017. Blood. 129:866. PubMed
  4. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  5. Sereni L, et al. 2018. J Allergy Clin Immunol. 142:1272. PubMed
  6. Nabar NR, et al. 2022. Autophagy. 18:204. PubMed
  7. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  8. De Simone G, et al. 2021. Immunity. :. PubMed
  9. Gubin MM, et al. 2018. Cell. 175:1014. PubMed
  10. Jiao S, et al. 2020. Cell. 179(5):1177-1190.e13.. PubMed
  11. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  12. Lee A, et al. 2022. Nat Commun. 13:549. PubMed
RRID
AB_312923 (BioLegend Cat. No. 102702)

Antigen Details

Structure
ADP-ribosyl hydrolase, 42 kD
Distribution

B cells, NK cells, T cell subset, brain, muscle, kidney

Function
Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor
CD31, hyaluronic acid
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Shubinsky G, et al. 1997. Immunity 7:315.
3. Cesano A, et al. 1998. J. Immunol. 160:1106.
4. Cockayne DA, et al. 1998. Blood 92:1324.

Gene ID
12494 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org
Go To Top Version: 2    Revision Date: 10/25/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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