- Clone
- W18259A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Methylmalonyl-CoA Mutase, Methylmalonyl Coenzyme A Mutase, MCM, Truncated Methylmalonyl-CoA Mutase Variant, MMUT, EC 5.4.99.2, Methylmalonyl-CoA Isomerase
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
936601 | 25 µg | 81€ | ||||
936602 | 100 µg | 203€ |
MUT encodes MCM (Methylmalonyl-CoA mutase), which resides in the mitochondria to metabolize branched and odd-chain fatty acids. Utilizing cobalamin as a cofactor, MCM also isomerizes methylmalonyl-CoA to make succinyl-CoA, an important intermediate in the Kreb’s Cycle. Mutations in the gene can lead to disruptions in amino acid metabolism and may alter lipid and glucose homeostasis.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Partial recombinant human MUT protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.2 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
When tested for ICC on 4% PFA-fixed HeLa cells, this clone produced punctate nuclear staining, which is inconsistent with the reported mitochondrial matrix localization of MUT. We therefore do not recommend this clone for the application.
- RRID
-
AB_2888896 (BioLegend Cat. No. 936601)
AB_2888896 (BioLegend Cat. No. 936602)
Antigen Details
- Structure
- MUT is a 750 amino acid protein with a predicted molecular weight of 83 kD.
- Distribution
-
MUT expression is localized to the cytosol and the mitochondria.
- Function
- Fatty-acid metabolism; isomerase
- Interaction
- Adenosylcobalamin (Adocbl)
- Antigen References
-
1. Janata J, et al. 1997. Hum. Mol. Gen. 6(9):1457-64.
2. Worgan LC, et al. 2006. Hum. Mutat. 27(1):31-43.
3. Mancia F, et al. 1998. Cell. 6(6):711-20.
4. Reid M, et al. 2017. Cell. 171(4):736-37.
5. Schneller J, et al. 2015. Mol. Ther. 23(1):70. - Gene ID
- 4594 View all products for this Gene ID
- UniProt
- View information about MUT on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-MUT Antibody | W18259A | WB |
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Purified anti-MUT Antibody
Whole cell lysates (15 µg) from the indicated cell lines wer...
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