- Clone
- SAM11 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Proteinase-activated receptor 2, thrombin receptor-like 1, G-protein coupled receptor 11, protease-activated receptor 2, coagulation factor II receptor-like 1
- Previously
-
Covance Catalog# MMS-5116
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
817201 | 100 µL | 220€ |
Proteinase-activated receptor 2 (PAR-2), also known as G-protein coupled receptor 1 or thrombin receptor-like 1, is a receptor for trypsin and trypsin-like enzymes coupled to G proteins. The function of PAR-2 is mediated through the activation of multiple signaling pathways, including MAPK, phospholipase C, intracellular calcium, and I-kappaB kinase/NF-kappaB and Rho. PAR-2 is involved in the regulation of innate and adaptive immunity, the modulation of inflammatory responses, and as a sensor of proteolytic enzymes generated during the course of infection. PAR-2 is also involved in the recruitment of leukocytes to inflammation sites, promotion of dendritic cell maturation and trafficking to lymph nodes, production of superoxide, and T-cell activation.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This monoclonal antibody was raised against human PAR-2 protein and was mapped to amino acids 37-50.
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
IHC-P - Quality tested
WB - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 10 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody is effective in formalin-fixed paraffin-embedded immunohistochemical staining (IHC-P) and immunoblotting (WB).
- Product Citations
-
- RRID
-
AB_2564810 (BioLegend Cat. No. 817201)
Antigen Details
- Structure
- Expected MW: 55 kD
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience
- Gene ID
- 2150 View all products for this Gene ID
- UniProt
- View information about PAR-2 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All PAR-2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-PAR-2 | SAM11 | IHC-P,WB |
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