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- Clone
- A18095C (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GAT-1, GABA Transporter
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot of purified anti-SLC6A1 antibody (clone A18095C). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 2 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 867401 | 25 µg | 85€ | ||||
| 867402 | 100 µg | 221€ | ||||
SLC6A1 is the gene that encodes GABA transporter 1 (GAT1) and functions as the major presynaptic protein in neurons involved in the removal of excessive GABA from the synaptic cleft and the extrasynaptic space. Diseases associated with GAT1 include neurodevelopmental disorders such as schizophrenia and seizure.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- KLH-conjugated C-terminal peptide of mouse SLC6A1.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Avoid boiling lysates before loading to SDS for WB.
- RRID
-
AB_2810801 (BioLegend Cat. No. 867401)
AB_2810801 (BioLegend Cat. No. 867402)
Antigen Details
- Structure
- GAT1 is a 599 amino acid protein with predicted and observed molecular mass of ~ 67 kD.
- Distribution
-
Tissue Distribution: Brain
Cellular Distribution: Plasma membrane - Function
- GAT1 is a GABA transporter protein that removes excessive GABA from the synaptic cleft and the extrasynaptic space.
- Interaction
- MPP5, STX1A
- Ligand/Receptor
- GABA
- Cell Type
- Astrocytes, GABAergic Neurons, Mature Neurons, Neurons, Oligodendrocytes
- Biology Area
- Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Zafar S, et al. 2018. Front Chem. 6:397.
- Lie MEK, et al. 2017. Adv. Neurobiol. 16:137-167.
- Zhou Y, Danbolt NC. 2013. Front Endocrinol (Lausanne). 4:165.
- Gene ID
- 6529 View all products for this Gene ID 232333 View all products for this Gene ID 79212 View all products for this Gene ID
- UniProt
- View information about SLC6A1 on UniProt.org
Other Formats
View All SLC6A1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-SLC6A1 | A18095C | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-SLC6A1
Western blot of purified anti-SLC6A1 antibody (clone A18095C...
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