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APC anti-human CD210b (IL-10RB) Antibody

Pricing & Availability
Clone
S17009F (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin 10 receptor subunit beta, CRFB4, CRF2-4, D21S58, D21S66, CDW210B
Isotype
Mouse IgG2a, κ
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Product Citations
publications
S17009F_APC_CD210b_Antibody_060221.png
Human peripheral blood lymphocytes were stained with HLA-DR FITC and CD210b (IL-10RB) (clone S17009F) APC (left) or mouse IgG2a, κ APC isotype control (right).
  • S17009F_APC_CD210b_Antibody_060221.png
    Human peripheral blood lymphocytes were stained with HLA-DR FITC and CD210b (IL-10RB) (clone S17009F) APC (left) or mouse IgG2a, κ APC isotype control (right).
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396805 25 tests 124€
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396806 100 tests 290€
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Description

CD210b is a Type 1 transmembrane glycoprotein also known as, subunit 2 (IL-10R2) and is an essential chain for the IL-10 receptor complex. The IL-10 receptor complex is made up of alpha (IL10-RA) and beta (IL-10RB) subunits. Coexpression of these subunits has been shown to be required for IL10 induced signal transduction. Binding of dimeric IL-10 to two alpha subunits can cause the recruitment of two beta subunits resulting in the transduction of the intracellular JAK/STAT pathway.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human IL10RB-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2892467 (BioLegend Cat. No. 396805)
AB_2892467 (BioLegend Cat. No. 396806)

Antigen Details

Structure
Type 1 transmembrane glycoprotein belonging to the cytokine receptor family.
Distribution

CD210b is expressed by a variety of cell types including T cells, B cells, NK cells, monocytes and macrophages.

Function
Activates STAT1, STAT3, Jak1, Tyk and is a component of cytokine receptor complexes specific for IL-22, IL-26, IL-28, and IL-29.
Ligand/Receptor
IL-10
Cell Type
B cells, Macrophages, NK cells, T cells, Thymocytes
Biology Area
Adaptive Immunity, Immunology, Signal Transduction
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
  1. Donnelly RP, et al. 2004. J Leukoc Biol. 76(2):314-321.  
  2. Koppelman B, et al. 1997. Immunity. (6): 861-871
  3. Kotenko SV, et al. 1997. EMBO J. 16(19):5894-5903. 
  4. Liu Y, et al. 1995. J Immunol. 152(4):1821-1829.
Gene ID
3588 View all products for this Gene ID
UniProt
View information about CD210b on UniProt.org
Go To Top Version: 1    Revision Date: 06-02-2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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