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APC anti-rat CD335 (NKp46) Antibody

Pricing & Availability
Clone
WEN23 (See other available formats)
Regulatory Status
RUO
Other Names
NCR1, NKP46, LY94
Isotype
Mouse IgG1, κ
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Product Citations
publications
WEN23_APC_CD335_Antibody_053018
Rat splenocytes were stained with rat CD161 FITC and rat CD335 (NKp46, clone WEN23) APC (left), or mouse IgG1, κ APC isotype control (right).
  • WEN23_APC_CD335_Antibody_053018
    Rat splenocytes were stained with rat CD161 FITC and rat CD335 (NKp46, clone WEN23) APC (left), or mouse IgG1, κ APC isotype control (right).
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250807 25 µg 120€
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250808 100 µg 266€
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Description

CD335, also known as NKp46, is a glycoprotein of the natural cytotoxicity receptor (NCR) family with 2 Ig-like domains and a short cytoplasmic tail. CD335 expression is restricted to NK cells and a subset of NKT cells; it's not expressed in CD1d-restricted NKT cells. NKp46 functions as a cytotoxicity triggering receptor.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Rat NKp46 ectodomain recombinant protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2734244 (BioLegend Cat. No. 250807)
AB_2734244 (BioLegend Cat. No. 250808)

Antigen Details

Structure
Single-pass type I membrane protein, 46 kD; belongs to the natural cytotoxicity receptor (NCR) family; contains 2 Ig-like (immunoglobulin-like) domains.
Distribution

Mature and immature NK cells, subset of NKT cells, but not on CD1d-restricted NKT cells.

Function
NK cells activation
Ligand/Receptor
Viral hemagglutinins, heparan sulfate proteoglycans
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References
  1. Westgaard IH, et al. 2004. J. Leuko. Biol. 76:1200.
  2. Falco M, et al. 1999. Immunol. Lett. 68:411.
  3. Caligiuri MA. 2008. Blood. 112:461.
Gene ID
117547 View all products for this Gene ID
UniProt
View information about CD335 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05-30-2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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