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APC/Cyanine7 anti-human CD56 (NCAM) Recombinant Antibody

Pricing & Availability
Clone
QA18A21 (See other available formats)
Regulatory Status
RUO
Other Names
Leu-19, NKH1
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA18A21_APC-CYA7_CD56_Antibody_1228223
Human peripheral blood lymphocytes stained with anti-human CD16 (clone 3G8) FITC and anti-human CD56 recombinant (clone QA18A21) APC/Cyanine7 (left) or mouse IgG1, κ APC/Cyanine7 isotype control (right).
  • QA18A21_APC-CYA7_CD56_Antibody_1228223
    Human peripheral blood lymphocytes stained with anti-human CD16 (clone 3G8) FITC and anti-human CD56 recombinant (clone QA18A21) APC/Cyanine7 (left) or mouse IgG1, κ APC/Cyanine7 isotype control (right).
Compare all formats See APC/Cyanine7 spectral data
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398813 25 tests 124€
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398814 100 tests 268€
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Description

CD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_3097438 (BioLegend Cat. No. 398813)

Antigen Details

Structure
Ig superfamily, single transmembrane or GPI-anchored glycoprotein
Distribution

NK cells, T subset, neural tissue, some LGL and myeloid leukemias

Function
Adhesion
Ligand/Receptor
Heparin sulfate
Cell Type
B cells, Leukemia, Mesenchymal Stem Cells, Neurons, T cells
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Rosental B, et al. 2011. J Immunol. 187:5693. PubMed
  2. Correia DV, et al. 2011. Blood. 118:992. PubMed
  3. Schlecker E, et al. 2014. Cancer Res. 74:3429. PubMed
  4. Snyder JM, et al. 2014. PLoS One. 9:e107257. PubMed
  5. Siebert N, et al. 2014. PLoS One. 9:e107692. PubMed
  6. Rider P, et al. 2015. J Immunol. 195:1705-12. PubMed
  7. Davis ZB, et al. 2011. J Vis Exp. 49: 2668. PubMed
  8. Robin JD, et al. 2015. J Vis Exp. 95: 52307. PubMed
  9. Ames E, et al. 2015. J Immunol. 195: 4010-9. PubMed
  10. Laroni A, et al. 2016. J Autoimmun. 72:8-18. PubMed
  11. Pachnio A, et al. 2016. PLoS Pathog. 12:e1005832. PubMed
  12. Wouters K, et al. 2017. Sci Rep. 7:42665. PubMed
Gene ID
4684 View all products for this Gene ID
UniProt
View information about CD56 on UniProt.org
Go To Top Version: 1    Revision Date: 12-28-2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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