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PE anti-mouse CD170 (Siglec-F) Antibody

Pricing & Availability
Clone
S17007L (See other available formats)
Regulatory Status
RUO
Other Names
Siglec-5
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
S17007L_PE_CD170_Antibody_082018
C57BL/6 mouse splenocytes were stained with CD193 (CCR3, clone J073E5 ) APC and CD170 (Siglec-F, clone S17007L) PE (left) or Rat IgG2a, κ PE isotype control (right).
  • S17007L_PE_CD170_Antibody_082018
    C57BL/6 mouse splenocytes were stained with CD193 (CCR3, clone J073E5 ) APC and CD170 (Siglec-F, clone S17007L) PE (left) or Rat IgG2a, κ PE isotype control (right).
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155505 25 µg 123€
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155506 100 µg 288€
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Description

CD170, also known as Siglec-F, Siglec-5, is a member of the Sialic acid-binding Ig-like lectin family, type I single pass transmembrane protein, with 4 extracellular Ig-like domains and 2 ITIM motifs in the cytoplasmic domain; preferentially binds [alpha]-2,3-linked sialic acid. Siglec F is expressed in eosinophils, alveolar macrophages and intestinal microfold (M) cells and induces apoptosis of the lung eosinophis during allergic asthma.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  2. Millar FR, et al. 2022. Cell Rep. 41:111596. PubMed
  3. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  4. Lin CH, et al. 2023. iScience. 26:106904. PubMed
  5. Ydens E, et al. 2020. Nat Neurosci. 23:676. PubMed
  6. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  7. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  8. Mathur S, et al. 2021. JCI Insight. 6:. PubMed
  9. Fantauzzi MF, et al. 2021. ERJ Open Res. 7: . PubMed
  10. Baasch S, et al. 2021. Cell. . PubMed
  11. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  12. Roberts LM, et al. 2021. iScience. 24:103025. PubMed
  13. Yadava K et al. 2019. Elife. 8 pii: e44821. PubMed
  14. Machácek T, et al. 2022. PLoS Pathog. 18:e1010302. PubMed
  15. Aktories P, et al. 2022. Cell Rep Methods. 2:100260. PubMed
  16. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  17. Rochford I, et al. 2021. Am J Physiol Lung Cell Mol Physiol. 321:L686. PubMed
  18. Chetty A, et al. 2021. Cell Host Microbe. 29:579. PubMed
  19. Li H, et al. 2021. J Clin Invest. 131:. PubMed
RRID
AB_2750234 (BioLegend Cat. No. 155505)
AB_2750234 (BioLegend Cat. No. 155506)

Antigen Details

Structure
Member of the Sialic acid-binding Ig-like lectin family, type I, single pass, transmembrane protein, 4 extracellular Ig-like domains, 2 ITIM motifs in the cytoplasmic domain
Distribution

Eosinophils, alveolar macrophages, intestinal microfold (M) cells

Function
Induces apoptosis in eosinophils
Ligand/Receptor
[alpha]-2,3-linked sialic acid
Cell Type
Eosinophils, Macrophages
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity
Molecular Family
CD Molecules, Siglec Molecules
Antigen References
  1. Gicheva N, et al. 2016. Biochem. Biophys. Res. Commun. 479:1.
  2. Kiwamoto T, et al. 2015. J. Allergy Clin. Immunol. 135:1329.
  3. Suzukawa M, et al. 2013. J. Immunol. 190:5939.
  4. Patnode ML, et al. 2013. J. Biol. Chem. 288:26533.
Gene ID
233186 View all products for this Gene ID
UniProt
View information about CD170 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 08-21-2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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