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PE anti-mouse DCIR4 (Clec4a1) Antibody

Pricing & Availability
Clone
MH7E7 (See other available formats)
Regulatory Status
RUO
Other Names
Clec4a1, DCIR4, Dcir4, dendritic cell inhibitory receptor 4
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
MH7E7_PE_DCIR4_Antibody_100620
C57BL/6 bone marrow cells were surface stained with CD11b FITC and DCIR4 (Clec4a1) (clone MH7E7) PE (left) or rat IgG1, κ PE isotype control (right).
  • MH7E7_PE_DCIR4_Antibody_100620
    C57BL/6 bone marrow cells were surface stained with CD11b FITC and DCIR4 (Clec4a1) (clone MH7E7) PE (left) or rat IgG1, κ PE isotype control (right).
See PE spectral data
Cat # Size Price Quantity Check Availability Save
162003 25 µg 123€
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162004 100 µg 288€
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Description

Clec4a1 or dendritic cell inhibitory receptor 4 (DCIR4) is a C-type lectin receptor (CLR) which belongs to DC immunoreceptor (DCIR) family. Inhibitory members of DCIR family are type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain. Studies indicate that inhibitory DCIRs play an anti-inflammatory role and that immunopathology related to rheumatoid arthritis and TB infection is driven by their loss. Inhibitory DCIR are found on DCs, B cells, monocytes, macrophages, and neutrophils, but not T or NK cells and relay signal through Src homology region 2 domain-containing phosphatase (SHP). DCIR4, yet to be confirmed to have inhibitory role, is exclusive to non-granulocytic myeloid cells and its expression level can be used to differentiate between patrolling and inflammatory monocytes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
DCIR4 reporter cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2888811 (BioLegend Cat. No. 162003)
AB_2888811 (BioLegend Cat. No. 162004)

Antigen Details

Structure
Type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain
Antigen References

1. Kameda Y, et al. 2016. Biochem. Biophys. Res. Commun. 480: 215-221
2. Hsu Y, et al. 2017. Biochem. Biophys. Res. Commun. 494: 440-445

Gene ID
269799 View all products for this Gene ID
UniProt
View information about DCIR4 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 10-06-2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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