- Clone
- W16209A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Myb, c-Myb, Transcriptional Activator Myb, Proto-oncogene c-Myb, MYB Proto-Oncogene, Transcription Factor
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
935301 | 25 µg | 81€ | ||||
935302 | 100 µg | 203€ |
c-Myb is a proto-oncogene protein that functions as a transcription factor and a key regulator of cell proliferation and differentiation. As a DNA binding protein, it plays a role in regulating cell cycle and gene expression. c-Myb expression is elevated in hematopoietic progenitor cells and decreases following cell differentiation. Increased or aberrant expression of c-Myb as well as duplication and c-terminal deletion have been reported in various malignancies suggesting it plays a critical role in tumorigenesis.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Partial recombinant protein of human MYB corresponding to amino acid residues 391-640
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IP - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg/mL. For immunoprecipitation, the suggested use of this reagent is 2.5 µg/test. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
- This clone is predicted to recognize isoforms 1, 2, 4, 7, and 8 based off complete sequence homology of the immunizing peptide and the corresponding region in each isoform.
- ICC test failed. The clone incorrectly stains the negative control in the cytosol.
- RRID
-
AB_2832893 (BioLegend Cat. No. 935301)
AB_2832893 (BioLegend Cat. No. 935302)
Antigen Details
- Structure
- Myb is a 640 amino acid protein with a predicted molecular weight of 72 kD.
- Distribution
-
Nucleus/differential expression
- Function
- Gene transcription, cell proliferation and differentiation
- Cell Type
- Epithelial cells, Leukemia
- Biology Area
- Cell Biology, Stem Cells, Transcription Factors
- Antigen References
-
- Schulz C, et al. 2012. Science. 336(6077):86-90.
- Martin C, et al. 1997. Trends Genet. 13(2):67-73.
- Mucenski M, et al. 1991. Cell. 65(4):677-89.
- Gene ID
- 4602 View all products for this Gene ID
- UniProt
- View information about c-Myb on UniProt.org
Other Formats
View All c-Myb Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-c-Myb | W16209A | WB,IP |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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