- Clone
- N10/7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Cavβ4, Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4, Voltage-Dependent L-Type Calcium Channel Subunit Beta-4, Calcium Channel Voltage-Dependent Subunit Beta 4
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
602452 | 100 µg | 132€ |
Voltage-dependent L-type calcium channel subunit beta-4 (Cavß4) is a member of the membrane-associated guanylate kinase (GK) protein family and a cytoplasmic subunit of voltage-gated calcium channels. Expressed predominantly in the cerebellum and kidney, it is responsible for calcium entry into nerve termini and subsequent neurotransmitter release via its association with membrane-trafficking protein synaptotagmin 1 (Syt 1). It regulates synaptic transmission, increases the readily releasable pool of synaptic vesicles, and plays a role in synaptic vesicle plasticity and maturation through its association with Cavß1, RIM1, and actin filaments (F-actin). Cavß4 has been linked to psychiatric and anxiety disorders including major depressive disorder (MDD) and schizophrenia and is a potential therapeutic target in their study and treatment.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic peptide corresponding to amino acids 458-474 of rat Cavβ4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone has been tested for IHC and failed.
- RRID
-
AB_2904448 (BioLegend Cat. No. 602452)
Antigen Details
- Structure
- Cavβ4 is a 520 amino acid protein with a predicted molecular weight of 58 kD.
- Distribution
-
Ubiquitously expressed but predominantly expressed in brain, cytosol and plasma membrane.
- Function
- Calcium channel, voltage-gated channel, ion channel
- Molecular Family
- Ion Channels, Neurotransmitter Receptors
- Antigen References
-
- Andrade A, et al. 2019. Int. J. Mol. Sci. 20:3537.
- Gustavo G, et al. 2019. Front. Cell. Neurosci. 13:125.
- Weiss N. 1999. J. Neurosci. 23:6117.
- Gene ID
- 785 View all products for this Gene ID
- UniProt
- View information about Cavbeta4 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Cavβ4 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Cavβ4 | N10/7 | WB |
Compare Data Across All Formats
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Purified anti-Cavβ4
Whole tissue membrane extracts (15 µg total protein) from hu...
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