- Clone
- A18174E (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GLYT-2, NET1, HKPX3, Glycine Transporter 2
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
870801 | 25 µg | 85€ | ||||
870802 | 100 µg | 221€ |
Glycine transporter 2 (GlyT2) protein is encoded by the SLC6A5 gene. It is one of the major glycine transporters that is expressed predominantly in the brain stem and spinal cord, and is frequently used as cellular marker for glycinergic neurons in the central nervous system. Mutations in the SLC6A5 gene have been clinically linked to hyperekplexia 3, which has been thought to be caused by disruption of inhibitory neuronal transmission.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic peptide corresponding to a.a. 182-199 of mouse SLC6A5
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1 - 5 µg/mL. For immunocytochemistry, a concentration range of 2 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2820198 (BioLegend Cat. No. 870801)
AB_2820198 (BioLegend Cat. No. 870802)
Antigen Details
- Structure
- GlyT2 is a 797 amino acid protein with predicted and observed molecular mass of ~87 kD.
- Distribution
-
Tissue Distribution: Brain
Cellular Distribution: Plasma Membrane - Function
- Glycine transport and recycling
- Ligand/Receptor
- Glycine
- Cell Type
- Mature Neurons, Neurons
- Biology Area
- Cell Biology, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins
- Antigen References
-
- Zafra F, et al. 2017. Adv Neurobiol. 16:55.
- Lopez-Corcuera B, et al. 2017. Adv Neurobiol. 16:13.
- Vandenberg RJ, et al. 2014. Trends Pharmacol Sci. 35(8):423.
- Gene ID
- 9152 View all products for this Gene ID 171148 View all products for this Gene ID
- UniProt
- View information about GlyT2 on UniProt.org
Related FAQs
Other Formats
View All GlyT2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-GlyT2 (SLC6A5) | A18174E | WB,ICC |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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