- Clone
- 7.13 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Adenomatosis polyposis coli down-regulated 1, B7323, DRAPC1, P7019
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
367302 | 100 µg | 212€ |
APCDD1 (adenomatosis polyposis coli down-regulated 1), also known as B7323, DRAPC1, or FP7019, is a 514 amino acid single-pass type I membrane protein. APCDD1 is expressed in the gastrointestinal tract, placental trophoblasts, and both epidermal and dermal compartments from human hair follicles. It is also weakly expressed in lymphoid tissues. APCDD1 has been reported to be directly regulated by the beta-catenin/ITF-2 complex and that its elevated expression promotes the proliferation of colonic epithelial cells. It is thought to function as a developmental target of the beta-catenin pathway and may play an important role in colorectal tumorigenesis. Recently, it was found to negatively regulate Wnt signaling in a cell-autonomous manner.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- Cynomolgus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human APCDD1-His.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. For immunocytochemistry, a concentration of 10 µg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2565749 (BioLegend Cat. No. 367302)
Antigen Details
- Structure
- 514 amino acid single-pass type I membrane protein.
- Distribution
-
Gastrointestinal track and placental trophoblastis, epidermal and dermal compartments of the hair follicle, and weak expression in lymphoid tissues.
- Function
- May regulate a diversity of biological process controlled by Wnt signaling, regulated by beta-catenin/ITF-2 complex.
- Interaction
- Plays an important role in colorectal tumorigenesis.
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Shimomura Y, et al. 2010. Nature 7291:1043.
2. Takahashi M, et al. 2002. Cancer Res. 20:5651. - Gene ID
- 147495 View all products for this Gene ID
- UniProt
- View information about APCDD1 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All APCDD1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human APCDD1 (DRAPC1) | 7.13 | FC,ICC |
PE anti-human APCDD1 (DRAPC1) | 7.13 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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-
Purified anti-human APCDD1 (DRAPC1)
Human colon adenocarcinoma cell line (SW480) cells were stai... Human colon adenocarcinoma cell line (SW480) cells were fixe... -
PE anti-human APCDD1 (DRAPC1)
Human colon adenocarcinoma cell line (SW480) cells, were sta...
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