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- Clone
- S23011E (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD158z, Killer Cell Immunoglobulin-Like Receptor 3DL3, KIR44, KIRC1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Ba/F3 cells transfected with human KIR3DL3 were stained with purified anti-human (CD158z) (KIR3DL3) (clone S23011E) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by goat anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 334908 | 100 µg | 338€ | ||||
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIMs and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.
CD158z is a glycoprotein with three extracellular Ig domains and a long cytoplasmic tail containing an ITIM motif. It is reportedly expressed on intraepithelial γδ and CD8+ T cells. KIR3DL3 has been reported to bind to HHLA2 (B7H7) to cause downstream functional inhibition.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- KIR3DL3-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Based on in-house testing on different KIR-expressing transfectants, clone S23011E does not interact with other KIR protein family members.
Antigen Details
- Structure
- Three Ig-like extracellular domain glycoprotein
- Distribution
-
Intraepithelial γδ and CD8+ T cells
- Function
- T Cell subset regulation
- Ligand/Receptor
- HHLA2
- Cell Type
- Lymphocytes, NK cells, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
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- Vilches C, et al. 2002. Annu. Rev. Immunol. 92.107361.
- Middleton D, et al. 2010. Immunol. 123:8.
- Bhatt RS, et al. 2021. Cancer Immunol. 2:156-169.
- Gene ID
- 115653 View all products for this Gene ID
- UniProt
- View information about CD158z on UniProt.org
Other Formats
View All CD158z Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD158z (KIR3DL3) Antibody | S23011E | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD158z (KIR3DL3) Antibody
Ba/F3 cells transfected with human KIR3DL3 were stained with...
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