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Purified anti-human CD41/CD61 Recombinant Antibody

Pricing & Availability
Clone
QA20A86 (See other available formats)
Regulatory Status
RUO
Other Names
gpIIb/gpIIIa
Isotype
Human IgG1, κ
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Product Citations
publications
QA20A86_PURE_CD41-CD61_Antibody_060722
Human peripheral blood platelets were stained with purified anti-human CD41/CD61 recombinant (clone QA20A86) (filled histogram) or purified human IgG1, κ isotype control (open histogram) and followed by PE anti-human IgG Fc.
  • QA20A86_PURE_CD41-CD61_Antibody_060722
    Human peripheral blood platelets were stained with purified anti-human CD41/CD61 recombinant (clone QA20A86) (filled histogram) or purified human IgG1, κ isotype control (open histogram) and followed by PE anti-human IgG Fc.
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383102 100 µg 190€
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Description

CD41/CD61, also known as gpIIb/IIIa, is a member of a family integrin receptors. This is a complex comprised by CD41 and CD61 through non-covalent association. CD41/CD61 is mainly expressed by platelets and megakaryocytes. The resting form of the CD41/CD61 complex is involved in platelet activation and aggregation by binding to immobilized fibrinogen. After activation, CD41/CD61 becomes a receptor for soluble fibrinogen and several other RGD-containing adhesive proteins such as von Willebrand Factor (vWF) and fibronectin. An absence or dysfunction of CD41/CD61 on the platelet surface results in an inherited bleeding disorder, called Glanzmann Thromsasthenia (GT). CD41/CD61 has been found on murine hematopoietic progenitor cells, indicating that this complex may play a role in regulating hematopoietic development.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Human
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2927828 (BioLegend Cat. No. 383102)

Antigen Details

Structure
Complex of CD41 and CD61 through non-covalent association
Distribution

Platelets and megakaryocytes

Function
Mediates attachment to cells of diverse matrix proteins
Ligand/Receptor
Fibrinogen, RGD-containing adhesive proteins such as vonWillebrand Factor (vWF) and fibronectin
Cell Type
Megakaryocytes, Platelets
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Gene ID
3690 View all products for this Gene ID 3674 View all products for this Gene ID
UniProt
View information about CD41/CD61 on UniProt.org
Go To Top Version: 1    Revision Date: 06-07-2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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