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Purified anti-mouse CD157 (BST-1) Antibody

Pricing & Availability
Clone
W21013C (See other available formats)
Regulatory Status
RUO
Other Names
cADPr hydrolase 2, Ly-65, BP-3, ADP-ribosyl cyclase 2, BST1
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W21013C_PURE_CD157_BST-1_Antibody_1_091924
C57BL/6 mouse bone marrow cells were stained with purified anti-mouse CD157 (BST-1) (clone W21013C) (left) or purified rat IgG2a, κ isotype control (right) followed by goat anti-rat IgG PE. Cells were then co-stained with anti-mouse CD45R/B220 (clone RA3-6B2) APC. Data shown are gated on the lymphoid population.
  • W21013C_PURE_CD157_BST-1_Antibody_1_091924
    C57BL/6 mouse bone marrow cells were stained with purified anti-mouse CD157 (BST-1) (clone W21013C) (left) or purified rat IgG2a, κ isotype control (right) followed by goat anti-rat IgG PE. Cells were then co-stained with anti-mouse CD45R/B220 (clone RA3-6B2) APC. Data shown are gated on the lymphoid population.
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167002 100 µg 140€
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Description

CD157, also known as ADP-ribosyl cyclase 2, BST-1 (bone marrow stromal cell antigen 1), and BP-3 antigen, is an ectoenzyme member of the ADP-ribosyl cyclase family. It has a molecular weight between 40 - 46 kD and is a GPI-linked cell membrane glycoprotein which is expressed as a homodimer. CD157 is expressed by macrophages, neutrophils, bone marrow stromal cells, endothelial cells, follicular dendritic cells, and T and B cell progenitors prior to the rearrangement of the antigen receptors. Besides the ectoenzyme activity, it also plays a role in neutrophil migration and adhesion.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CD157 transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone W21013C does not affect the binding of clone BP-3 on target cells.

Antigen Details

Structure
Member of the ADP-ribosyl cyclase family, ectoenzyme, 40-46 kD, glycosyl-phosphatidylinositol (GPI)- anchored membrane protein, present on the cell surface as a homodimer
Distribution

Expressed by endothelial cells, follicular dendritic cells, cells from the myeloid lineage, and T and B cell precursors prior to the rearrangement of the antigen receptor. Expressed in many cell types from different tissues like the bone marrow, spleen, thymus, lung, kidney, and heart.

Function
Synthesizes cyclic ADP-ribose (cADPR)
Cell Type
B cells, Dendritic cells, Endothelial cells, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References
  1. Yamamoto-Katayama S, et al. 2002. J Mol Biol. 316:711-23.
  2. Funaro A, et al. 2009. Front Biosci. 14:929-43.
  3. Malavasi F, et al. 2006. Mol Med. 12:334-41.
  4. Vicari AP, et al. 1996. Int Immunol. 8:183-91.
Gene ID
12182 View all products for this Gene ID
UniProt
View information about CD157 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09-19-2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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