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Purified anti-mouse Jagged 2 Antibody

Pricing & Availability
Clone
HMJ2-1 (See other available formats)
Regulatory Status
RUO
Other Names
HJ2, Jagged2, Jagged-2 precursor, JAG2
Isotype
Armenian Hamster IgG
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Product Citations
publications
HMJ2-1_Pure_100908.jpg
FJ2/CHO transfectant cell line stained with HMJ2-1 purified, followed by anti-hamster IgG PE
  • HMJ2-1_Pure_100908.jpg
    FJ2/CHO transfectant cell line stained with HMJ2-1 purified, followed by anti-hamster IgG PE
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Description

The Notch receptors and their ligands are highly conserved from invertebrates to mammals. The Jagged-2 is one of the several Notch ligands identified. The binding to Notch receptor results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. Jagged-2 is reported to be essential for the regulation of spermatogenesis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
CHO cells expressing murine Jagged-2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References
  1. Moriyama Y, et al. 2008. Int. Immunol. 20:763 (FC)
Product Citations
  1. Duran CL, et al. 2023. Breast Cancer Res. 25:37. PubMed
  2. Sharma VP, et al. 2021. Nat Commun. 12:7300. PubMed
RRID
AB_1227682 (BioLegend Cat. No. 131001)

Antigen Details

Structure
A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). After a single transmembrane domain (TM) is a short in
Distribution
Testicular tissues and spermatids
Function
The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell development, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect the target cells. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate.
Ligand/Receptor
Notch receptors
Cell Targets
Skeletrophin binds the intracellular regions of Jagged-2, but not those of Delta-1,3,4, or Jagged-1.
Biology Area
Immunology
Antigen References

1. Ehebauer MT, et al. 2006. Biochem J 392:13
2. Shimizu K, et al. 2000. Mol Cell Biology 20:18
3. Hellstrom M, et al. 2007. Nature 445:776
4. Luo B, et al. 1997. Mol Cell Biol. 17:6057

Gene ID
16450 View all products for this Gene ID
UniProt
View information about Jagged 2 on UniProt.org
Go To Top Version: 1    Revision Date: 11-30-2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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