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- Clone
- MEL62 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CSPG4, Chondroitin Sulfate Proteoglycan 4
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot of purified anti-NG2 antibody (clone MEL62). Lane 1: Molecular weight marker; Lane 2: 40 µg of human brain lysate; Lane 3: 40 µg of mouse brain lysate; Lane 4: 40 µg of rat brain lysate. The blot was incubated with 10 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system. Mouse and rat brain lysates were included as negative control to demonstrate the specificity of this antibody to human NG2.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 867701 | 25 µg | 85€ | ||||
| 867702 | 100 µg | 221€ | ||||
CSPG4, best known as neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that is frequently used as a marker for oligodendrocyte progenitor cells. NG2 plays an important role in cell proliferation and migration. It also stabilizes cell-substratum interactions during early events in melanoma cell invasion on the endothelial basement membranes. Missense mutations in NG2 are segregated in familial forms of schizophrenia, implicating its role in neurodevelopmental disorders.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2814616 (BioLegend Cat. No. 867701)
AB_2814616 (BioLegend Cat. No. 867702)
Antigen Details
- Structure
- CSPG4 is a 2322 amino acid protein with predicted molecular mass of ~ 250 kD and observed molecular mass of ~ 260-280 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Extracellular, plasma membrane, lysosome, and Golgi apparatus - Function
- NG2 is involved in cell proliferation and migration, and plays an important role in stabilizing cell-substratum interactions.
- Interaction
- MPDZ, PRKCA, TNC, Laminin-1, COL5A1, COL6A2
- Cell Type
- Oligodendrocytes
- Biology Area
- Cancer Biomarkers, Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability, Cell Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Antigen References
-
- Schäfer MKE and Tegeder I. 2018. Matrix Biol. 68-69:571.
- Birey F, et al. 2017. Curr Opin Neurobiol. 47:93.
- Song FE, et al. 2017. CNS Neurosci Ther. 23(7):547.
- Gene ID
- 1464 View all products for this Gene ID
- UniProt
- View information about NG2 on UniProt.org
Other Formats
View All NG2 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-NG2 | MEL62 | WB |
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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-NG2
Western blot of purified anti-NG2 antibody (clone MEL62). La...
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