- Clone
- NAP-07 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- LAT2 (linker for activation of T cells family), member 2, LAB
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
627102 | 100 µg | 235€ |
Non-T cell activation Linker (NTAL) is a transmembrane adaptor protein with an apparent molecular weight of 30 kD expressed on B cells, natural killer (NK) cells, and myeloid cells. The NTAL protein is found in rafts, which are membrane microdomains that participate in B cell activation. NTAL interacts with a variety of proteins including Grb2, PLC gamma 2, and PLC gamma 1. This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant cytoplasmic domain (91-243 a.a.) of human NTAL.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel. For IHC, use a 15 µl/ml dilution of antibody for staining. Antigen retrieval for IHC of formalin-fixed paraffin-embedded tissue using 0.01 M sodium citrate buffer is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
NOTE: For flow cytometric staining with this clone, True-Nuclear™ Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended.
- Product Citations
-
- RRID
-
AB_2133251 (BioLegend Cat. No. 627102)
Antigen Details
- Structure
- 30 kD double palmitoylated protein gene that consists of 14 exons, and its alternative splicing generates three transcript variants.
- Distribution
-
B, natural killer cells, monocytes, mast cells, and activated T cells.
- Function
- Involved in FCER1 mediated signaling in mast cells and as a negative regulator of early B cell signaling. May also be involved in CFCGR1 mediated signaling in myeloid cells. Couples activation of these receptors with distal intracellular events through the recruitment of Grb2.
- Ligand/Receptor
- Membrane microdomains (rafts) of B cells, natural killer (NK) cells, and myeloid cells.
- Cell Type
- B cells, NK cells, Monocytes, Mast cells, T cells
- Biology Area
- Cell Biology, Immunology, Signal Transduction
- Antigen References
-
1. Yamasaki S, et al. 2007. Mol. Cell Biol. 27(12):4406-15.
2. Brdicka T, et al. 2002. J. Exp. Med. 196(12):1617-26.
3. Tkaczyk C, et al. 2004. Blood 104(1):207-14.
4. Volna P, et al. 2004. 200(8):1001-13.
5. Lebduska P, et al. 2007. 328(1-2):139-51. - Gene ID
- 7462 View all products for this Gene ID
- UniProt
- View information about NTAL on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All NTAL (LAT2) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-NTAL | NAP-07 | WB,IHC-P |
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