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- Clone
- 2D9/TSPAN8 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Tspan8, tetraspanin-8
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Rat colorectal cancer cell line ACL-15 stained with purified anti-rat TSPAN8 (clone 2D9/TSPAN8) followed by anti-mouse IgG, PE (filled histogram) or mouse IgG2a, κ purified isotype control followed by anti-mouse IgG, PE (open histogram).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 200802 | 100 µg | 238€ | ||||
Tetraspanins, also referred to as the transmembrane 4 superfamily (TM4SF) proteins, have four transmembrane alpha-helices and two extracellular domains. It acts as molecular facilitators forming a web between themselves and a multitude of molecules. It is also involved in adhesion, motility, matrix modulation and cell fusion. Tetraspanins/Tetraspanin-complexes are constitutive components of exosomes. During exosome assembly, Tetraspanins become internalized via a tyrosine-based internalization motif. Internalized membrane microdomains are recruited into early endosomes from where they can become incorporated into multivesicular body (MVB), which migrate towards and fuse with the cell membrane releasing invaginated endosomes as exosomes.
Product DetailsProduct Details
- Verified Reactivity
- Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2941445 (BioLegend Cat. No. 200802)
Antigen Details
- Structure
- Four transmembrane alpha-helices and two extracellular domains
- Distribution
-
Multi-pass membrane protein
- Function
- Adhesion, motility, matrix modulation and cell fusion
- Interaction
- LIPR1, MEP1B, STX1-2, TIM23, S38A7
- Ligand/Receptor
- Integrin binding
- Biology Area
- Immunology
- Antigen References
-
- Berditchevsk F, et al. 2001. Journal of Cell Science. 114 (Pt 23): 4143–51.
- Mu W, et al. 2020. Cells. 9:319.
- Gene ID
- 171048 View all products for this Gene ID
- UniProt
- View information about TSPAN8 on UniProt.org
Related FAQs
Other Formats
View All TSPAN8 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-rat TSPAN8 | 2D9/TSPAN8 | FC |
| Purified anti-rat TSPAN8 | 2D9/TSPAN8 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-rat TSPAN8
Rat colorectal cancer cell line ACL-15 stained with anti-rat... -
Purified anti-rat TSPAN8
Rat colorectal cancer cell line ACL-15 stained with purified...
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