Login / Register 
United States ($) USD
Austria (€) EUR
Belgium (€) EUR
Finland (€) EUR
France (€) EUR
Germany (€) EUR
Ireland (€) EUR
Japan (¥) JPY
Luxembourg (€) EUR
Netherlands (€) EUR
Switzerland (CHF) CHF
United Kingdom (£) GBP
- Clone
- 2B1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- SMN1, SMN, SMN2, SMNT, GEMIN1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot of purified anti-SMN (Gemin 1) antibody (clone 2B1). Lane 1: Molecular weight marker; Lane 2: 20 µg of HeLa cell lysate; Lane 3: 20 µg of HepG2 cell lysate. The blot was incubated with 2 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 862801 | 25 µg | 85€ | ||||
| 862802 | 100 µg | 221€ | ||||
SMN1/Gem-associated protein 1 (Gemin 1) is a component of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. The SMN complex localizes to the cytosol and nucleus of eukaryotic cells. Mutations of SMN1 lead to spinal muscular atrophy.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC, IHC-F - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
-
- Kobayashi M, et al. 2017. Disease Models & Mechanisms. (10):215 (IHC-F)
- Spiro Z, et al. 2016. Scientific Reports. (6):27470 (ICC)
- Yong J, et al. 2004. Molecular and Cellular Biology. 24(7):2747 (WB)
- RRID
-
AB_2810753 (BioLegend Cat. No. 862801)
AB_2810753 (BioLegend Cat. No. 862802)
Antigen Details
- Structure
- SMN1 is a 294 amino acid protein with an apparent molecular mass of ~ 32 kD.
- Distribution
-
Tissue Distribution: Brain, pancreas, gallbladder, bladder, testis, lymph node, and bone marrow
Cellular Distribution: Nucleus and cytosol - Function
- SMN1 is a component of the SMN complex essential for the formation of snRNP complexes in Eukaryotic cells.
- Interaction
- SMN1 forms homodimers or found in complex with other SMN/GEMIN proteins.
- Cell Type
- Neurons
- Biology Area
- Chromatin Remodeling/Epigenetics, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors
- Antigen References
-
- Maretina MA, et al. 2018. Curr Genomics. 19(5):339
- Singh RN, et al. 2018. Adv Neurobiol. 20:31
- Groen EJN, et al. 2018. Nat Rev Neurol. 14(4):214
- Gene ID
- 6606 View all products for this Gene ID 6607 View all products for this Gene ID
- UniProt
- View information about SMN on UniProt.org
Other Formats
View All SMN Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-SMN (Gemin 1) | 2B1 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-SMN (Gemin 1)
Western blot of purified anti-SMN (Gemin 1) antibody (clone ...
Follow Us